The Glutathione Status of Cells

doi:10.1016/S0074-7696(08)60166-7

International Review of Cytology

Volume 54, 1978, Pages 109-160

https://doi.org/10.1016/S0074-7696(08)60166-7 Get rights and content

Publisher Summary

Glutathione (GSH) is the most important nonprotein thiol in living systems and is of widespread occurrence in the intracellular milieu of animals, plants, and microorganisms. GSH was isolated and named by the English biochemist Frederick Gowland Hopkins. This chapter discusses GSH status, the biologically relevant chemistry of GSH, the forms in which GSH can be present within the cell, along with the GSH content of cells and the methods for analysis of this substance. GSH-related biochemical reactions and the biological roles of GSH are discussed in the chapter. The use of perturbations in GSH status as a means for investigating GSH-related phenomena and an analysis of the consequences of perturbation are presented. A short summary of genetic lesions related to GSH is also included. Like chemically induced perturbations in GSH status, genetic lesions provide valuable insights into the role of GSH in normal functions and processes in cells. The chapter concludes with some brief comments about the future of the relationship of GSH status to cellular processes.

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¹: This article is dedicated to the memory of Dr Chaim Sheba, who provided, with warmth and wisdom, the original stimulus for our studies on the importance of glutathione.

²: Present address: Depts. of Medicine and Chemistry, University of California, San Diego, La Jolla, California.

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The Glutathione Status of Cells1

Publisher Summary

Int. J. Biochem.

J. Biol. Chem.

Biochim. Biophys. Acta

J. Biol. Chem.

Biochim. Biophys. Acta.

Biochem. Biophys. Res. Commun.

Blood

FEBS Lett.

Anal. Biochem.

J. Biol. Chem.

Brain Res.

Life Sci.

Biochem. Med.

J. Biol. Chem.

Biochem. Biophys. Res. Commun.

J. Biol. Chem.

Arch. Biochem. Biophys.

Exp. Eye Res.

J. Biol. Chem.

Biochim. Biophys. Acta

Biochim. Biophys. Acta

Biochem. Biophys. Res. Commun.

Biochem. Biophys. Res. Commun.

Biochim. Biophys. Acta

Biochim. Biophys. Acta

Biochim. Biophys. Acta

Exp. Cell Res.

FEBS Lett.

Biochim. Biophys. Acta

Anal. Biochem.

J. Biol. Chem.

Biochim. Biophys. Acta

Ann. Intern. Med.

Semin. Hematol.

Glutathione: Metabolism and Function

Radiat. Biol.

N. Engl. J. Med.

J. Physiol. (London)

Proc. Natl. Acad. Sci. U.S.A.

Ann. N.Y. Acad. Sci.

Biochemistry

Biochem. Biophys. Res. Commun.

Biochem. J.

J. Cell Biol.

Brain Res.

The Glutathione Status of Cells¹