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A Critique of Fixed and Progressive Ratio Schedules Used to Examine the Neural Substrates of Drug Reinforcement

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Abstract

This paper is a critique of fixed and progressive ratio schedules used to examine the neural substrates of cocaine reinforcement. The discussion focuses on problems encountered while examining the effects of neurotoxic lesions and pharmacological pretreatments on cocaine reinforcement. We review the theoretical and interpretational problems associated with the use of the fixed ratio (FR) schedules that have been used in the majority of studies, and we conclude that rate of drug intake cannot directly address the issue of increased or decreased reinforcer efficacy. The progressive ratio (PR) schedule offers some advantages over FR schedules, although it is now clear that the same implementation cannot be applied across all drug classes. It is likely that the motivation to self-administer psychostimulant vs. opiate drugs is qualitatively different. We conclude that there is no single schedule that can quantify all aspects of drug reinforcement and that behavioral paradigms will need to be adapted according to the particular question under study.

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Acknowledgements

This work was supported by the Medical Research Council of Canada. J.M.A. is supported by a Studentship from FCAR (Fonds pour la Formation de Chercheurs et l’Aide a la Recherche).

References (70)

  • A. McGregor et al.

    Effect of medial prefrontal cortex injections of SCH 23390 on intravenous cocaine self-administration under both a fixed and progressive ratio schedule of reinforcement

    Behav. Brain Res.

    (1995)
  • S. Rassnick et al.

    The effects of 6 hydroxydopamine lesions of the nucleus accumbens and the mesolimbic dopamine system on oral self administration of ethanol in the rat

    Brain Res.

    (1993)
  • N.R. Richardson et al.

    Antagonism of cocaine self-administration by the preferential dopamine autoreceptor antagonist, (+)-AJ 76

    Brain Res.

    (1993)
  • N.R. Richardson et al.

    Fluoxetine pretreatment reduces breaking points on a progressive ratio schedule reinforced by intravenous cocaine self-administration in the rat

    Life Sci.

    (1991)
  • N.R. Richardson et al.

    Progressive ratio schedules in drug self-administration studies in ratsA method to evaluate reinforcing efficacy

    J. Neurosci. Methods

    (1996)
  • N.R. Richardson et al.

    A single injection of either flupenthixol decanoate or haloperidol decanoate produces long-term changes in cocaine self-administration in rats

    Drug Alcohol Depend.

    (1994)
  • M.E. Risner et al.

    Intravenous self-administration of fencamfamine and cocaine by beagle dogs under fixed-ratio and progressive-ratio schedules of reinforcement

    Drug Alcohol Depend.

    (1986)
  • D.C.S. Roberts

    Breaking points on a progressive ratio schedule reinforced by intravenous apomorphine increase daily following 6-hydroxydopamine lesions of the nucleus accumbens

    Pharmacol. Biochem. Behav.

    (1989)
  • D.C.S. Roberts et al.

    Increased self-administration of cocaine following haloperidolEffect of ovariectomy, estrogen replacement, and estrous cycle

    Pharmacol. Biochem. Behav.

    (1987)
  • D.C.S. Roberts et al.

    Disruption of cocaine self-administration following 6-hydroxydopamine lesions of the ventral tegmental area in rats

    Pharmacol. Biochem. Behav.

    (1982)
  • D.C.S. Roberts et al.

    Extinction and recovery of cocaine self-administration following 6-hydroxydopamine lesions of the nucleus accumbens

    Pharmacol. Biochem. Behav.

    (1980)
  • D.C.S. Roberts et al.

    Lesions of central serotonin systems affect responding on a progressive ratio schedule reinforced either by intravenous cocaine or by food

    Pharmacol. Biochem. Behav.

    (1994)
  • M.C. Wilson et al.

    Cholinergic influence on intravenous cocaine self-administration by rhesus monkeys

    Pharmacol. Biochem. Behav.

    (1973)
  • K.A. Zito et al.

    Disruption of cocaine and heroin self-administration following kainic acid lesions of the nucleus accumbens

    Pharmacol. Biochem. Behav.

    (1985)
  • R. Balon

    Fluoxetine for cocaine dependence in methadone maintenance

    J. Clin. Psychopharmacol.

    (1994)
  • R.L. Balster et al.

    Fixed-interval schedule of cocaine reinforcementEffect of dose and infusion duration

    J. Exp. Anal. Behav.

    (1973)
  • M.A. Bozarth et al.

    Involvement of the ventral tegmental dopamine system in opioid and psychomotor stimulant reinforcement

    NIDA Res. Monogr.

    (1985)
  • M.E. Carroll et al.

    Effects of food FR and food deprivation on disruptions in food-maintained performance of monkeys during phencyclidine withdrawal

    Psychopharmacology

    (1991)
  • M.E. Carroll et al.

    Intravenous cocaine self-administration in rats is reduced by dietary l-tryptophan

    Psychopharmacology

    (1990)
  • A.C. Catania

    Drug effects and concurrent performances

    Pharmacol. Rev.

    (1976)
  • S.L. Cohen et al.

    Effects of reinforcement history on responding under progressive-ratio schedules of reinforcement

    J. Exp. Anal. Behav.

    (1994)
  • R.L. Corwin et al.

    AnorecticsEffects on food intake and self-administration in rhesus monkeys

    Alcohol Drug Res.

    (1987)
  • J.M. Deminiére et al.

    6-Hydroxydopamine lesion of the dopamine mesocorticolimbic cell bodies increases (+)-amphetamine self-administration

    Psychopharmacology

    (1984)
  • G. Deneau et al.

    Self-administration of psychoactive substances by the monkey

    Psychopharmacology

    (1969)
  • J. Dougherty et al.

    Fixed-interval schedules of intravenous cocaine presentation in rats

    J. Exp. Anal. Behav.

    (1973)
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