Research LettersOrally active prostacyclin analogue in primary pulmonary hypertension
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2023, Journal of Thrombosis and HaemostasisPharmacologic strategies in neonatal pulmonary hypertension other than nitric oxide
2016, Seminars in PerinatologyCitation Excerpt :There are limited data on its use in infants.52 Beraprost sodium (BPS, Dorner® 20 µg tablet, Toray Industries Inc, Tokyo, Japan) is an oral formulation developed in Japan with a half-life of 35–40 min, and has been shown to improve pulmonary hypertension in adults53,54 and children with congenital heart disease.55,56 In a case series of seven infants with PPHN refractory to alkali therapy and high frequency ventilation, beraprost reduced OI but also decreased systemic blood pressure by an average of 11 mmHg by 6 h.57 In this study, infants received 1 µg/kg of beraprost every 6 h.
A comparative study of PGI<inf>2</inf> mimetics used clinically on the vasorelaxation of human pulmonary arteries and veins, role of the DP-receptor
2013, Prostaglandins and Other Lipid MediatorsCitation Excerpt :Unlike epoprostenol and iloprost, treprostinil has a long half-life, allowing its administration by continuous subcutaneous injection, thus avoiding the risk of infection related to continuous long term intravenous administration [14,15]. Beraprost is the first PGI2 analogue available as an oral formulation [16]. Currently, treprostinil and selexipag (and its metabolite MRE-269 = ACT-333679) are other orally available PGI2 mimetics in clinical development (Phase III) for the treatment of PAH [17,18].
Recent advances and future perspectives in therapeutic strategies for pulmonary arterial hypertension
2012, Journal of CardiologyCitation Excerpt :The clinical effects of iloprost are similar to epoprostenol and treprostinil, and superior to them with regard to inducible infections. Beraprost was the first oral drug for PAH [20,21], although its effects subside after half a year of use. Therefore, beraprost has only been approved and used in Japan.
Vascular effects of prostacyclin: Does activation of PPARδ play a role?
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