Research LettersNevirapine-associated Stevens-Johnson syndrome
References (5)
- et al.
Drug hypersensitivity reactions and human immunodeficiency virus disease
J Acquir Immune Dejic Syndr
(1992) - Caumes E, Saiag P, Picard C, et al. Sulfonamide-induced toxic epidermal necrolysis (TEN) and Stevens-Johnson syndrome...
Cited by (95)
Insights into the role of bioactivation mechanisms in the toxic events elicited by non-nucleoside reverse transcriptase inhibitors
2012, Advances in Molecular ToxicologyCitation Excerpt :Despite unequivocal benefits, a pitfall of NVP regimens is their association with serious and clinically restrictive idiosyncratic side effects. Severe, life-threatening, and in some cases, fatal liver and skin toxicity have been reported in patients treated with NVP [26–30]. The most likely dangerous toxic events in the skin are a morbilliform eruption (13–28% of patients) and a systemic HSR or severe rash (with an incidence of 8%) that is the major cause of drug discontinuation [26–28,31].
Cutaneous toxicities of antiretroviral therapy for HIV: Part II. Nonnucleoside reverse transcriptase inhibitors, entry and fusion inhibitors, integrase inhibitors, and immune reconstitution syndrome
2010, Journal of the American Academy of DermatologyCitation Excerpt :Other adverse effects of nevirapine have included case reports of oral ulcers (Fig 2) and cases of acute generalized exanthematous pustulosis, both of which resolved with discontinuation of nevirapine, and a patient with the development of a white plaque on the buccal mucosa associated with xerostomia and a burning sensation that resolved following cessation of nevirapine.13-15 SJS has also been reported in association with nevirapine, and nevirapine is one of the more common causes of SJS in the developing world, where nevirapine is frequently used2,4,16,17 (Fig 3). Although oral glucocorticoids and cetirizine have been shown to be ineffective in preventing nevirapine-associated hypersensitivity, an escalating dose scale for nevirapine has been established that decreases the risk of systemic hypersensitivity reaction.18,19
Dermatology of the Patient with HIV
2010, Emergency Medicine Clinics of North AmericaCitation Excerpt :These include SJS, TEN, and severe hypersensitivity reactions. Organ failure, including hepatic failure, has been reported.26,27 Scleral icterus and jaundice occur in 7% to 8% of patients taking atazanavir.28
Paediatric HIV-related skin diseases
2009, Diagnostic HistopathologyCitation Excerpt :Adverse reactions to NNRTIs such as nevirapine are not uncommon. Although an exanthematous eruption is encountered most frequently, SJS (Figures 6 and 7), TEN and DRESS may also occur.26–28,30–32 Lipodystrophy syndrome is a frequent complication of the PIs and may occur in children.26,28,29,33
Consideration of Nevirapine Analogs To Reduce Metabolically Linked Hepatotoxicity: A Cautionary Tale of the Deuteration Approach
2023, Chemical Research in ToxicologyFactors Predicting the Outcome of Stevens–Johnson Syndrome and Toxic Epidermal Necrolysis: A 5-Year Retrospective Study
2021, Indian Dermatology Online Journal