Elsevier

The Lancet

Volume 351, Issue 9102, 21 February 1998, Page 567
The Lancet

Research Letters
Nevirapine-associated Stevens-Johnson syndrome

https://doi.org/10.1016/S0140-6736(98)24008-6Get rights and content

References (5)

  • PJ Bayard et al.

    Drug hypersensitivity reactions and human immunodeficiency virus disease

    J Acquir Immune Dejic Syndr

    (1992)
  • Caumes E, Saiag P, Picard C, et al. Sulfonamide-induced toxic epidermal necrolysis (TEN) and Stevens-Johnson syndrome...
There are more references available in the full text version of this article.

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