Comparison of polymerically stabilized PEG-grafted liposomes and physically adsorbed carboxymethylchitin and carboxymethyl/glycolchitin liposomes for biological applications
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Cardiovascular drug delivery: A review on the recent advancements in nanocarrier based drug delivery with a brief emphasis on the novel use of magnetoliposomes and extracellular vesicles and ongoing clinical trial research
2020, Journal of Drug Delivery Science and TechnologyCitation Excerpt :In a recent report, liposomes targeted to ICAM-1, VCAM-1, fibrinogen, fibrin and TF, along with applying ultrasound waves, enhanced the targeted vessel wall following 5 min of IV liposome administration [19]. Different approaches like coating liposomes with inert, biocompatible polymers like PEG, PLGA etc. have been done to attain a sustained release profile of the drugs in-vivo [18]. The coating protects the liposomes from opsonin based reorganization and their subsequent clearance.
Interactions of serum with polyelectrolyte-stabilized liposomes: Cryo-TEM studies
2014, Colloids and Surfaces B: BiointerfacesLipid-Coated Calcium Phosphate Nanoparticles for Nonviral Gene Therapy
2014, Advances in GeneticsCitation Excerpt :Such a dense barrier to opsonization (adsorption of proteins such as antibodies, complement, and fibronectin) thus limits the potential for immune recognition of PEGylated liposomes, conferring in part the increases in circulation time observed in such nanoparticle systems (Haynes & Huang, 2013; Huang & Liu, 2011). Various polymeric materials have been developed (e.g., alcohols (Takeuchi, Kojima, Yamamoto, & Kawashima, 2000), saccharides (Mobed & Chang, 1998), amino acids (Metselaar et al., 2003)), and issues regarding PEGylation as a stealth system have been reviewed extensively (Knop et al., 2010); however, the material’s widespread utility provides a relevant comparative basis for formulation development. One of the physical parameters most unique to LCP relates to one’s ability to explore liposome PEGylation under the concept of what is known as the “supported bilayer,” as described in Chapter 4 (Li & Huang, 2009).
Preparation and evaluation of liposome-encapsulated codrug LMX
2012, International Journal of PharmaceuticsCitation Excerpt :It is reasonable to conclude that the charged particles may repel each other and prevent aggregation or precipitation happening, thus resulting in good stability. The negative or neutral liposomes provide more effective barrier to plasma macromolecular protein adsorption and are easy to resuspend in blood (Mobed and Chang, 1998). The process of freeze-drying did not affect the particle size of rehydrated LMX-loaded liposomes containing sucrose as cryoprotectant (ratio of sucrose to lipids, 1.3:1–2:1, w/w), the mean diameter was 213.7 ± 6.12 nm before lyophilization and 217.7 ± 3.14 nm after lyophilization/rehydration.
Preparation, characterization and in vivo evaluation of 2-methoxyestradiol-loaded liposomes
2010, International Journal of PharmaceuticsLayersome: Development and optimization of stable liposomes as drug delivery system
2007, International Journal of Pharmaceutics
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