Elsevier

Cell Calcium

Volume 24, Issues 5–6, November–December 1998, Pages 325-332
Cell Calcium

Invited review
Calcium permeability of ligand-gated channels

https://doi.org/10.1016/S0143-4160(98)90056-2Get rights and content

Abstract

Ligand-gated channels activated by excitatory neurotransmitters; glutamate, acetylcholine, ATP or serotonin are cation channels permeable to Ca2+. Molecular cloning revealed a large variety of the ligand-gated channel subunits differentially expressed in mammalian brain. Many of them have different Ca2+ permeability providing immense diversity in Ca2+ entry mediated by ligand-gated channels during synaptic transmission. Functional analysis of cloned channels allowed to identify structural elements in the pore forming regions determining Ca2+ permeability for many types of ligand-gated channels. The functional role of the Ca2+ entry mediated by various ligand-gated channels in mammalian central nervous system is less understood. The studies reviewed in this article provide information about known structural determinants of Ca2+ permeability of the ligand-gated channels and the role of this particular pathway of Ca2+ entry in cell function.

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