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Receptor localization in the mammalian dorsal horn and primary afferent neurons

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Abstract

The dorsal horn of the spinal cord is a primary receiving area for somatosensory input and contains high concentrations of a large variety of receptors. These receptors tend to congregate in lamina II, which is a major receiving center for fine, presumably nociceptive, somatosensory input. There are rapid reorganizations of many of these receptors in response to various stimuli or pathological situations. These receptor localizations in the normal and their changes after various pertubations modify present concepts about the wiring diagram of the nervous system. Accordingly, the present work reviews the receptor localizations and relates them to classic organizational patterns in the mammalian dorsal horn.

References (341)

  • D. Besse et al.

    Up-regulation of [3H]DAMGO and [3H]DTLET opioid binding sites in laminae I–II of the spinal cord intact and deafferented morphine-tolerant rats

    Neurosci. Lett.

    (1992)
  • B. Bettler et al.

    Cloning of a novel glutamate receptor subunit, GluR5: expression in the nervous system during development]

    Neuron

    (1990)
  • S. Bohlhalter et al.

    Inhibitory neurotransmission in rat spinal cord: co-localization of glycine- and GABAA-receptors at GABAergic synaptic contacts demonstrated by triple immunofluorescence staining

    Brain Res.

    (1994)
  • J. Bormann et al.

    GABAC receptors

    TINS

    (1995)
  • M.-L. Bouthenet et al.

    A detailed mapping of dopamine D-2 receptors in rat central nervous sysrtem by autoradiography with [125]iodosulpride

    Neuroscience

    (1987)
  • N.G. Bowery et al.

    GABAA and GABAB receptor site distribution in the rat central nervous system

    Neuroscience

    (1987)
  • A.T. Bruinvels et al.

    Evidence for the presence of 5-HTIB receptor messenger RNA in neurons of the rat trigeminal ganglia

    Eur. J. Pharmacol.

    (1992)
  • G. Bruning et al.

    Postnatal development of [3H]flunitrazepam and [3H]strychnine binding sites in rat spinal cord localized by quantitative autoradiography

    Neurosci. Lett.

    (1990)
  • S.H. Buck et al.

    Pharmacologic characterization and autoradiographic distribution of binding sites for iodinated tachykinins in the rat central nervous system

    Peptides

    (1986)
  • S.M. Carlton et al.

    Localization and activation of glutamate receptors in unmyelinated axons of rat glabrous skin

    Neurosci. Lett.

    (1995)
  • S.M. Carlton et al.

    Localization and activation of substance P receptors in unmyelinated axons of rat skin

    Brain Res.

    (1996)
  • J.M. Castro-Lopes et al.

    Complex changes of GABAA and GABAB receptor binding in the spinal cord dorsal ham following peripheral inflammation or neurectomy

    Brain Res.

    (1995)
  • C.G. Charlton et al.

    Ontogeny of substance P receptors in rat spinal cord: quantitative changes in receptor number and differential expression in specific loci

    Brain Res.

    (1986)
  • R.M. Chinnery et al.

    Autoradiographic distribution of binding sites for the non-NMDA receptor antagonist [3H]CNQX in human motor cortex, brainstem and spinal cord

    Brain Res.

    (1993)
  • K. Chung et al.

    The effects of dorsal rhizotomy and spinal cord isolation on calcitonin gene-related peptide-labeled terminals in the rat lumbar dorsal horn

    Neurosci. Lett.

    (1988)
  • J.A. Danks et al.

    A comparative autoradiographic study of the distributions of substance P and eledoisin binding sites in rat brain

    Brain Res.

    (1986)
  • G. Daval et al.

    Autoradiographic evidence of serotonin1 binding sites on primary afferent fibres in the dorsal horn of the rat spinal cord

    Neurosci. Lett.

    (1987)
  • H. De Vos et al.

    Imidazoline receptors, non-adrenergic idazoxan binding sites and α2-adrenoreceptors in the human central nervous system

    Neuroscience

    (1994)
  • C. Desprat et al.

    Ontogeny of neuropeptide FF pharmacology and receptors in mouse brain

    Dev. Brain Res.

    (1994)
  • M.M. Dietl et al.

    Substance P receptors in the human spinal cord: decrease in amyotrophic lateral sclerosis

    Brain Res.

    (1989)
  • Y.-Q. Ding et al.

    Co-localization of μ-opioid receptor-like and substance P-like immunoreactivity in axon terminals within the superficial layers of the medullary and spinal dorsal horns of the rat

    Neurosci. Lett.

    (1995)
  • Y.-Q. Ding et al.

    Spinoparabrachial tract neurons showing substance P receptor-like immunoreactivity in the lumbar spinal cord of the rat

    Brain Res.

    (1995)
  • A. Dubois et al.

    Autoradiographic distribution of the D1 agonist [3H]SKF 38393 in the rat brain and spinal cord. Comparison with the distribution of D2 dopamine receptors

    Neuroscience

    (1986)
  • P.K. Eide et al.

    Relief of post-herpetic neuralgia with N-methyl-d-aspartic acid receptor antagonist ketamine: a double blind cross-over comparison with morphine and placebo

    Pain

    (1994)
  • R. Elde et al.

    Localization of neuropeptide receptor mRNA in rat brain: initial observation using probes for neurotensin and substance P receptors

    Neurosci. Lett.

    (1990)
  • R.L.M. Faull et al.

    Benzodiazepine receptors in the human spinal cord: a detailed anatomical and pharmacological study

    Neuroscience

    (1986)
  • R.L.M. Faull et al.

    Opiate receptors in the human spinal cord: a detailed anatomical study comparing the autoradiographic localization of [3H] diprenorphine binding sites with the laminar pattern of substance P, myelin and Nissl staining

    Neuroscience

    (1987)
  • R.L.M. Faull et al.

    Neurotensin receptors in the human spinal cord: a quantitative autoradiographic study

    Neuroscience

    (1989)
  • C.T. Fischette et al.

    Effects of 5,7-dihydroxytryptamine on serotonin1 and serotonin2 receptors throughout the rat central nervous system using quantitative autoradiography

    Brain Res.

    (1987)
  • A. Frostholm et al.

    Glycine receptor distribution in mouse CNS: autoradiographic localization of [3H]strychnine binding sites

    Brain Res. Bull.

    (1985)
  • M. Fujita et al.

    Regional distribution of the cells expressing glycine receptor β subunit mRNA in the rat brain

    Brain Res.

    (1991)
  • T. Furuyama et al.

    Region-specific expression of subunits of ionotropic glutamate receptors (AMPA-type KA-type and NMDA receptors: in the rat spinal cord with special reference to nociception

    Mol. Brain Res.

    (1993)
  • T. Furuyama et al.

    Co-expression of glycine receptor β subunit and GABAA receptor S subunit mRNA in the rat dorsal root ganglion cells

    Mol. Brain Res.

    (1992)
  • M.T. Galeazza et al.

    Changes in [125I]hCGRP binding in rat spinal cord in an experimental model of acute peripheral inflammation

    Brain Res.

    (1992)
  • M.G. Garry et al.

    Quantitative autoradiographic analysis of [125I-human CGRP binding sites in the dorsal horn of rat following chronic constriction injury or dorsal rhizotomy

    Peptides

    (1991)
  • D.R. Gehlert et al.

    Localization of 5-HT3 receptors in the rat brain using [3H]LY278584

    Brain Res.

    (1991)
  • D.R. Gehlert et al.

    Distribution of [125I125I]angiotensin II binding sites in the rat brain: a quantitative autoradiographic study

    Neuroscience

    (1986)
  • C. Gouardéres et al.

    High resolution radioautographic localizations of [125I125I]FK-33-824-labelled mu opioid receptors in the spinal cord of normal and deafferented rats

    Neuroscience

    (1991)
  • C. Gouardéres et al.

    Autoradiographic localization of mu delta and kappa opioid receptor binding sites in rat and guinea pig spinal cord

    Neuropeptides

    (1985)
  • C. Gouardéres et al.

    Opioid and substance P receptor adaptations in the rat spinal cord following sub-chronic intrathecal treatment with morphine and naloxone

    Neuroscience

    (1993)
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