Full-length reviewReceptor localization in the mammalian dorsal horn and primary afferent neurons
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Menthol facilitates excitatory and inhibitory synaptic transmission in rat medullary dorsal horn neurons
2021, Brain ResearchCitation Excerpt :Therefore, changes in the excitability of medullary dorsal horn neurons, via a network of local interneurons and primary afferent fibers, likely plays an important role in the processing of nociceptive transmissions (Yoshimura and Jessell, 1990; Yoshimura and Nishi, 1995; Furue et al., 2004; Todd, 2017). The regulation of nociceptive transmission in the dorsal horn region occurs due to the modulation of both excitatory but also GABAergic and/or glycinergic inhibitory transmissions (Todd et al., 1996; Coggeshall and Carlton, 1997). Transient receptor potential (TRP) channels contribute to the sensory transduction of signals from peripheral tissues, in response to a wide variety of stimuli, including temperature and nociceptive stimuli (Tominaga, 2007).
The role of spinal inhibitory neuroreceptors in the antihyperalgesic effect of warm water immersion therapy
2021, Brazilian Journal of Physical TherapyCitation Excerpt :This hypothesis is plausible since it is known that sensory nerve endings also express a number of receptors for neurotransmitters that can inhibit pain transmission. Many of these receptors were characterized initially in the dorsal spinal cord,5 some receptors that are synthesized in the cell body of dorsal root ganglia cells and transported centrally to reside presynaptically on primary afferent neurons are also transported peripherally.25 We raised the question of whether spinal opioid receptors could be involved in WWIT-induced analgesia.
Antinociceptive activity of a polysaccharide from the roots of Sophora flavescens
2016, International Journal of Biological Macromolecules
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