Research reportOmega-3 polyunsaturated fatty acid levels in the diet and in red blood cell membranes of depressed patients
Section snippets
Background
It has been suggested that abnormal cell membrane fatty acid composition may be of aetiological significance in depression (Smith, 1991, Hibbeln and Salem, 1995). Cell membranes contain a phospholipid bilayer. Changes in the polyunsaturated fatty acid content of this phospholipid alters membrane micro structure. This can have profound effects upon neurotransmitter receptor function (Stubbs, 1992, Salem and Niebylski, 1995).
The polyunsaturated fatty acids (PUFAs) are classified into two main
Methods
Ten cases with a diagnosis of a major depressive episode according to DSM IV criteria were recruited into the study. None were suffering from physical illness of severity or nature which might be associated with abnormal n-3 fatty acid levels. All were taking antidepressant medication. The cases were matched with 14 healthy control subjects with no history of psychiatric disorder. They were also matched in terms of age, gender, social class, body mass index, number of children, recent life
Results
Patients and controls showed a similar distribution of age (patients 38.7±10.2; controls 39.4±10.9) and gender (patients 8F 2M, controls 12F 2M) and did not differ significantly in smoking habit (patients 7/10 smokers, controls 8/14 smokers) recent life events (patients 8/10 recent life events, controls 6/14) or alcohol habit (patients 1.0±1.4 units per day; controls 0.8±0.8 units per day). BDI score was 26.9±4.7 in the depressed patients and 4.9±4.2 in the controls.
As shown in Fig. 1 and Table
Discussion
We have confirmed our previous finding (Peet et al., 1997) that PUFAs of the n-3 series are significantly depleted in RBC membranes from depressed patients. The absolute values and the magnitude of the differences in the n-3 PUFA series were not significantly different from the previous findings.
Although patient numbers were small, the results are highly significant and in the predicted direction. The findings are consistent with other recent studies of fatty acid levels in phospholipid and
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