Short communicationDistribution of mRNA encoding a nitrobenzylthioinosine-insensitive nucleoside transporter (ENT2) in rat brain
Section snippets
Acknowledgements
Research was supported by the Medical Research Council of Canada. F.E.P. is a scholar of the Medical Research Council of Canada. C.E.C. is a Terry Fox Cancer Research Scientist of the National Cancer Institute of Canada. J.D.Y. is a Heritage Medical Scientist of the Alberta Heritage Foundation for Medical Research. C.M.A. was a trainee of the Heart and Stroke Foundation of Canada.
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Cited by (64)
Of adenosine and the blues: The adenosinergic system in the pathophysiology and treatment of major depressive disorder
2021, Pharmacological ResearchCitation Excerpt :However, it must be noted that studies using in situ hybridization have found evidence for marked ENT1 mRNA expression in both the hippocampus and the cerebellum of rats [83]. ENT2 expression extensively overlaps that of ENT1 [84], with mRNA expression being observed in cortical, striatal, thalamic, hippocampal, and cerebellar neurons [85]. Unlike ENTs 1 and 2, ENT3 is primarily located in the intracellular space, having an especially relevant role in lysosomal functioning [86].
Nucleoside transporters in the purinome
2014, Neurochemistry InternationalCitation Excerpt :In this mini-review, we highlight possible future avenues of research into the regulation of ENTs in the CNS. Although all ENTs have been found in the brain (Anderson et al., 1999a,b; Baldwin et al., 2005; Alanko et al., 2006; Dahlin et al., 2007; for a review, see Parkinson et al., 2011), most studies focus on ENT1 and ENT2, since these were the first ENTs to be discovered. ENT3 and ENT4 were described more recently (Kong et al., 2004).
Functional expression of drug transporters in glial cells: Potential role on drug delivery to the CNS
2014, Advances in PharmacologyDifferential adenosine uptake in mixed neuronal/glial or purified glial cultures of avian retinal cells: Modulation by adenosine metabolism and the ERK cascade
2011, Biochemical and Biophysical Research CommunicationsCitation Excerpt :Three subtypes of concentrative transporters promote nucleoside influx in a sodium-dependent manner [7]. On the other hand, there are four described subtypes of equilibrative transporters, which promote sodium-independent nucleoside transport according to the concentration gradient [7], and ENT1 and ENT2 are the predominant isoforms expressed in the CNS [8,9]. Concerning the enzymes, adenosine kinase (ADK) and ADA are the main players in adenosine inactivation.
Behavioral effects of elevated expression of human equilibrative nucleoside transporter 1 in mice
2011, Behavioural Brain ResearchCitation Excerpt :Adenosine can be formed intracellularly or extracellularly and is transported through cell membranes via nucleoside transporters [3,4]. Nucleoside transport in neurons and glia is predominantly mediated by equilibrative nucleoside transporters 1 and 2 (ENT1, ENT2) [5,6]. To examine the role of ENTs in regulating adenosine levels and adenosine receptor activity, transgenic mice that express human ENT1 (hENT1) under the control of a neuron specific enolase promoter have been developed [7].