The Transcriptional Activation Pattern of Lipopolysaccharicle Binding Protein (LBP) Involving Transcription Factors AP-1 and C/EBPβ
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Quantitative indices of dynamics in concentrations of lipopolysaccharide-binding protein (LBP) as prognostic factors in severe sepsis/septic shock patients - Comparison with CRP and procalcitonin
2011, Clinical BiochemistryCitation Excerpt :Nevertheless, some of biomarkers are commonly assessed in clinical practice, lipopolysaccharide-binding protein (LBP) among them. LBP is a liver-synthesized glycoprotein belonging to the first class of acute phase proteins, the expression of which is triggered by synergistic activity of interleukins (IL) 1 and 6 [6,7]. It seems to play a double role in inflammation by enhancing host response to lipopolysaccharide (LPS) challenge at physiologically low concentrations but conferring protection against effects exerted by LPS at high concentrations, present during acute phase [8,9].
Lipopolysaccharide binding protein promoter variants influence the risk for Gram-negative bacteremia and mortality after allogeneic hematopoietic cell transplantation
2008, BloodCitation Excerpt :This finding provides novel insight into the complex biology of the innate immune response to LPS and GN infections. LBP is a secretory class I acute-phase protein, whose gene is transcriptionally activated by APRF/STAT3 and other cytokine-inducible nuclear proteins, such as AP-1 and C/EBPβ.10,29 Transcription of the LBP gene is also induced by IL-1β alone, synergistically by IL-1β and IL-6, or by tumor necrosis factor-α and dexamethasone, resulting in maximal circulating LBP concentrations within 24 to 48 hours after LPS challenge.30,31
Ethanol consumption decreases the synthesis of the mannose 6-phosphate/insulin-like growth factor II receptor but does not decrease its messenger RNA
2003, Biochemical PharmacologyCitation Excerpt :Both the elevation and decline of the latter mRNAs by ethanol occur with a concomitant increase or decrease in the proteins they encode [21,30–32]. Nuclear run-on assays and mRNA half-life studies showed that the ethanol-elicited increase in LBP mRNA level is due to activation of transcription factors AP-1 and C/EBP-β as well as to ethanol-elicited LBP mRNA stabilization [33,34]. The mechanisms for the ethanol-induced reduction of ASGPR mRNA and the elevation of TGF-β1 mRNA are not known.
Localization of regulatory elements mediating constitutive and cytokine-stimulated plasminogen gene expression
2002, Journal of Biological ChemistryCitation Excerpt :Two possible candidates for transcriptional repressors are octamer factor 1 (Oct-1) and activator protein 1 (AP-1). Oct-1 and AP-1 are ubiquitously expressed and both can function as either activators or repressors of transcription (40-44). Similarly, removal of the homologous region on the human plasminogen gene (−709 to −515 bp) resulted in a modest increase in luciferase activity suggesting the presence of a repressor within this region as well (Fig.5 B).
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R. R. Schumann, M.D., Institute of Microbiology, University Medical Center ≪Charité≫,Humboldt-University, Dorotheenstraße 96, D-10117 Berlin, Germany, Phone: +49-30-9406-3849, Fax: +49-30-9406-3532, e-mail: [email protected]