ArticlesAge-Related Increases in Brain Monoamine Oxidase B in Living Healthy Human Subjects
Section snippets
Subjects
A total of 21 normal subjects, ages 23–86 (average age: 51.3 ± 19.4 years; nonsmokers; 12 men and 9 women) were recruited for this study. Exclusion criteria included history of neurological or psychiatric disorder; head trauma with loss of consciousness; alcohol or substance abuse (except for caffeine and nicotine) and medical conditions that may alter cerebral functioning. Prescan tests ensured the absence of any psychoactive drug use and most of the subjects (15 of 21) received a
Results
The model term λk3, which is a function of MAO B concentration showed a significant increase with age (p < 0.004) in all brain regions examined except for the cingulate gyrus (with a trend for the parietal cortex). Correlation coefficients for brain regions with significant increases with age (p < 0.01) were positive and ranged from 0.60 to 0.74. The results of correlation analysis are shown in Table 1 and individual values for the frontal cortex are shown in Fig. 1A. The same patterns
Discussion
The main findings from this PET study in healthy subjects are that brain MAO B increases with age in all regions examined (except the cingulate gyrus) and that age-related increases in MAO B in living subjects are small relative to those reported for postmortem studies. For example, the whole brain and the cortical regions and the basal ganglia, thalamus, pons and cerebellum showed an average increase of 7.1 ± 1.3%/decade (Table 2) over the age range 23 to 86 years. The frontal cortex showed an
Acknowledgements
This work was supported by Brookhaven National Laboratory (BNL) under contract DE-AC02-76CH00016 with the U.S. Department of Energy and supported by its Office of Health and Environmental Research and by National Institutes of Health Grant NS 15380. The authors thank Alfred Wolf, Richard Ferrieri, David Schlyer, Robert Carciello, Donald Warner, Thomas Martin, Noelwah Netusil, Carol Redvanly, Payton King, Ivana Zezulkova and Lois Caligiuri for their advice and assistance in various parts of this
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