Structure-activity relationship studies on (4-acylpyrrol-2-yl)alkanoic acids as inhibitors of the cytosolic phospholipase A2: Variation of the alkanoic acid substituent, the acyl chain and the position of the pyrrole nitrogen
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Pyrrole alkanoic acid derivatives as nuisance inhibitors of microsomal prostaglandin E <inf>2</inf> synthase-1
2012, European Journal of Medicinal ChemistryCitation Excerpt :This paper reports the effects of the structural variation of this lead compound on its mPGES-1 inhibitory properties. Quite a few of the pyrroles evaluated for mPGES-1 inhibition have already been published (13–16,18,19,31,34) [35,36,38,39]. For the synthesis of numerous of the dodecanoyl-substituted target compounds (35,43–45,55–67,75) similar synthetic routes were applied as for the preparation of their known corresponding octadecanoyl and octadecyl derivatives, respectively [35,36,38,39].
Thermodynamic characterization of cytosolic phospholipase A<inf>2</inf> alpha inhibitors
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2017, European Journal of Organic Chemistry
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