Lung resistance protein (LRP) expression in human normal tissues in comparison with that of MDR1 and MRP
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A comprehensive review on acridone based derivatives as future anti-cancer agents and their structure activity relationships
2022, European Journal of Medicinal ChemistryUp-down regulation of HIF-1α in cancer progression
2021, GeneCitation Excerpt :Studies are looking for a way to enhance oxygen level in cells to overcome hypoxia-induced radio-resistance in tumor cells with increasing blood flow and targeting or destroying hypoxic cells (Comerford et al., 2002). Also, some chemotherapeutic agents (alkylating agents) find decreased efficacy on hypoxic tumor cells, as these kinds of agents need oxygen for maximum activity (Sugawara et al., 1997). These finding resulted in formulation of different chemotherapeutic agents which are fully operating with low amounts of oxygen (Sugawara et al., 1997).
Nanoporous gold electrode prepared from two-step square wave voltammetry (SWV) and its application for electrochemical DNA biosensing of lung resistance related protein (LRP) gene
2019, Journal of Electroanalytical ChemistryCitation Excerpt :Consequently, the detecting LRP gene expression in peripheral blood serves as an effective marker to acquire drug resistance information of NSCLC patients and to design a responsive latter treatment plan for patients [28]. Nowadays, immunohistochemical and RT-PCR techniques are the main methods for the detection and diagnosis of the LRP expression [29], however, there have been still some limitations in these methods, such as time consuming, technical difficulty and expensiveness [30,31]. Thus, it is imperative to develop an effective diagnostic protocol for LRP gene with sensitivity, simplicity and inexpensiveness in clinical assay.
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2019, Environment InternationalMultidrug resistance: Physiological principles and nanomedical solutions
2013, Advanced Drug Delivery ReviewsElectrochemical immunoassay on expression of integrin Β1 on tumor cells and drug-resistant tumor cells
2012, Biosensors and BioelectronicsCitation Excerpt :The identification of drug resistance mechanisms offers a potential strategy for improving the efficacy of cancer chemotherapy. In general, MDR is correlated to drug efflux transporters (P-glycoprotein, Hall et al., 2009; multidrug resistance protein, Liang et al., 2010; lung resistance protein, Sugawara et al., 1997, etc.), apoptosis-regulating genes (p53, Rouby et al., 1993; Caspase 3, Li et al., 2010; Bcl-2, Ha et al., 2011; Bax, Wang et al., 2009, etc.) and relevant enzymes (cytochrome P450, Rawal et al., 2010; glutathine S-transferase, Haves and Pulford, 1995; DNA Topoisomerase II, Byl et al., 2001, etc.). Mammalian cells can be grown either in suspension or adherent manner.
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Present address: Pathology Research Division, The Research Institute of Tuberculosis, 3-1-24 Matsuyama, Kiyose, Tokyo 204, Japan. Fax: +81 424 924600.