Elsevier

Neuroscience Letters

Volume 287, Issue 3, 30 June 2000, Pages 183-186
Neuroscience Letters

Distribution of P2X purinoceptor clusters on individual rat dorsal root ganglion cells

https://doi.org/10.1016/S0304-3940(00)01150-2Get rights and content

Abstract

The distribution of P2X receptors on the cell bodies of acutely dissociated rat dorsal root ganglion cells has been determined using immunohistochemistry. Only medium and small ganglion cells showed P2X receptor labelling, which took the form of receptor clusters 0.2–0.5 μm in diameter. P2X3 was the predominant cluster type although clusters of all other subtypes, P2X1, P2X2, P2X4, P2X5 and P2X6 were observed. There was little evidence for colocalization of the different receptor subtypes pointing to very little heteropolymerization of P2X receptors in the ganglion.

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