Lowering glucose concentrations increases cytosolic Ca2+ in orexin neurons of the rat lateral hypothalamus
Section snippets
Acknowledgements
This research was supported in part by grants from the Ministry of Education, Science, Sports and Culture of Japan (to T.Y.).
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Cited by (65)
A free-choice high-fat diet modulates the effects of a sucrose bolus on the expression of genes involved in glucose handling in the hypothalamus and nucleus accumbens.
2020, Physiology and BehaviorCitation Excerpt :This phenomenon is referred to as glucose-sensing. For example, low extracellular glucose concentrations alter the activity of orexin neurons in the lateral hypothalamus [11]. Secondly, the hedonic properties of sucrose drinking will activate neuronal pathways, which will cause an increase in fuel utilization of glucose in these neurons.
Glucosensing and glucose homeostasis: From fish to mammals
2011, Comparative Biochemistry and Physiology - B Biochemistry and Molecular BiologyCitation Excerpt :More recently, evidence has also emerged that the AMP-kinase (AMPK) plays a key role in the sensing pathway used by GI neurons (McCrimmon, 2008). Although initially it was shown that orexin-A/hypocretin-1 was not present in rat GI neurons (Liu et al., 2001; Parton et al., 2007), other studies have demonstrated an acute inhibition of orexin/hypocretin neurons by glucose in the mouse brain (Muroya et al., 2001; Yamanaka et al., 2003), suggesting that the glucosensing sensitivity can be also species-dependent in mammals. Interestingly, the glucose responses of orexin/hypocretin cells displaying a unique sugar selectivity, are also insensitive to GK inhibitors and cannot be mimicked by the intracellular ATP, suggesting that they do not require conventional glucose-metabolizing machinery (González et al., 2008).
Pretreatment with subeffective doses of Rimonabant attenuates orexigenic actions of orexin A-hypocretin 1
2008, NeuropharmacologyCitation Excerpt :Thus, it is possible that hypothalamic orexin A-hypocretin 1 participates in short term regulation of appetite through delaying satiety mechanisms, as suggested by previous studies where orexin A-hypocretin 1 inhibits the onset of the behavioral satiety sequence in rats in a time- and dose-dependent manner, delaying the normal sequence eating–grooming–resting (Rodgers et al., 2000). The influence of previous meals found in our study is in agreement with reports showing how the metabolic status of animals influences their feeding response to orexin A. Thus, acute hypoglycemia increases prepro-orexin mRNA in the lateral hypothalamus (Griffond et al., 1999), up-regulates orexin receptors (Sakurai et al., 1998) and activates orexin-containing neurons in the lateral hypothalamus (Muroya et al., 2001). Moreover, several authors suggest that orexin A-hypocretin 1-containing neurons regulate short-term energy homeostasis via sensitivity to blood glucose levels (Thorpe et al., 2003; Kotz et al., 2002).
Physiological mechanisms integrating metabolism and reproduction
2006, Knobil and Neill's Physiology of ReproductionOrexins: The ‘multitasking’ neuropeptides in the energy metabolism and immune regulation of male reproduction
2021, Chemical Biology Letters