An investigation of the neuroprotective effect of lithium in organotypic slice cultures of rat hippocampus exposed to oxygen and glucose deprivation
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Protective effects of lithium chloride on seizure susceptibility: Involvement of α<inf>2</inf>-adrenoceptor
2015, Pharmacology Biochemistry and BehaviorCitation Excerpt :Since then lithium has been the drug of choice for the treatment of different CNS disorders due to its antidepressant and anti-manic properties (Chiu and Chuang, 2010; Price and Heninger, 1994). In addition, lithium also shows neuroprotective character in different in vivo and in vitro settings (Cimarosti et al., 2001; Manji et al., 1999) including antiepileptic properties (Ghasemi and Dehpour, 2011; Ghasemi et al., 2010; Minabe et al., 1988). Regarding to these protective effects, evaluation of lithium administration on different brain disorders like seizure, have been the subject of many studies (Bahremand et al., 2010a,b; Ghasemi et al., 2010).
Berberine was neuroprotective against an in vitro model of brain ischemia: Survival and apoptosis pathways involved
2014, Brain ResearchCitation Excerpt :The medium was changed twice a week and experiments were carried out after 14 days in vitro. The induction of OGD was based on the method described by Strasser and Fischer (1995) with some modifications (Cimarosti et al., 2001). Cultures were carefully rinsed three times with OGD medium composed of CaCl2 1.26 mM, KCl 5.36 mM, NaCl 136.9 mM, H2PO4 0.34 mM, MgCl2 0.49 mM, MgSO4 0.44 mM, HEPES 25 mM, pH 7.2.
Differential regulation of gabab receptor trafficking by different modes of n-methyl-d-aspartate (NMDA) receptor signaling
2014, Journal of Biological Chemistry