Low stringency hybridization study of the dopamine D4 receptor revealed D4-like mRNA distribution of the orphan seven-transmembrane receptor, APJ, in human brain
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Role of apelin/APJ system in hypothalamic-pituitary axis
2019, Clinica Chimica ActaCitation Excerpt :In their study, they found that APJ receptors were widely expressed in the following rat brain tissues, such as striatum, hippocampus, cerebellum and cortex [1]. Besides, APJ was also detected in the white matter region of the human brain [2]. These findings indicate that endogenous ligands of the APJ receptor may play a pivotal role in the transmission of information in the brain.
Induction of antinociceptive tolerance to the chronic intrathecal administration of apelin-13 in rat
2016, NeuropeptidesCitation Excerpt :However, activated or non-activated APJ may affect Ang II-AT1 signaling (Sun et al., 2011). Apelin/APJ system also are distributed in central nerve system, spanal cord (Matsumoto et al., 1996; O'Carroll et al., 2000; Reaux et al., 2001) hypothalamus, cortex, cerebellum, hippocampus, midbrain, striatum, pituitary (Lee et al., 2000; Medhurst et al., 2003), amygdale, raphe nucleus (Reaux et al., 2002) and peripheral areas such as heart, kidney, skeletal muscle, liver, lung, intestine, colon and glands (Habata et al., 1999; Hekmat et al., 2011; Hosoya et al., 2000; Kawamata et al., 2001; Najafipour et al., 2012; O'Carroll et al., 2000; Wang et al., 2004). Interestingly, apelin plays an important role in the neuronal signaling pathway (O'Carroll et al., 2000).
Neuroprotective effect of the endogenous neural peptide apelin in cultured mouse cortical neurons
2010, Experimental Cell ResearchEmerging roles of apelin in biology and medicine
2005, Pharmacology and TherapeuticsIdentification of a Hydroxypyrimidinone Compound (21) as a Potent APJ Receptor Agonist for the Potential Treatment of Heart Failure
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