Journal of Chromatography B: Biomedical Sciences and Applications
Determination of ranitidine and its metabolites in human urine by reversed-phase ion-pair high-performance liquid chromatography
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A mechanistic insight into the shrinkage and swelling of Ca-montmorillonite upon adsorption of chain-like ranitidine in an aqueous system
2023, Journal of Colloid and Interface ScienceSeizing forbidden drug ranitidine by illite and the adsorption mechanism study
2022, Colloids and Surfaces A: Physicochemical and Engineering AspectsCitation Excerpt :The research results are the key starting point for entering the field test. Ranitidine hydrochloride (two pKa = 8.2 and 2.7; molar mass=350.86 g/mol) [25] (Figs. S1 and S2) was provided by Swiss Pharmaceutical Co., Ltd, Taiwan. The water solubility of RT was 660 mg/mL and the solubility in the pH range 1–7.4 was experimentally found to be over 550 mg/mL acting as a highly soluble [26].
D-glucose elicits significant increase in the oral bioavailability of model BCS class III drugs in the rabbit
2019, Journal of Drug Delivery Science and TechnologyCitation Excerpt :The drug inhibits gastric acid secretion when stimulated by food, histamine, pentagastrin [5,6]. Ranitidine HCl has two pKa values of 2.7 and 8.2, partition coefficient (log P) of 0.20, aqueous solubility of 660 mg/ml, and its molecular weight is 350 gm/mol [7–10]. Ranitidine HCl is completely dependent on the paracellular convective pathway in its absorption from the small intestine [11].
Ozonation of ranitidine: Effect of experimental parameters and identification of transformation products
2016, Science of the Total EnvironmentCitation Excerpt :RAN was found in the effluents of STPs in Greece at a median level of 1059 ng L− 1 (Dasenaki and Thomaidis, 2015b) and in river waters of Spain at a median concentration of 396.5 ng L− 1 (Valcárcel et al., 2011). It is excreted partly as an untransformed (30–70%) compound in urine and partly as its main metabolites, RAN N-oxide, N-desmethyl RAN and RAN S-oxide (Carey et al., 1981; Martin et al., 1981), in urine and feces. The removal of RAN in ultrapure water and wastewater samples has already been studied through the application of electrochemical processes (Carlesi Jara et al., 2007), ozonation competitive kinetics (Rivas et al., 2009), photochemical oxidation (Latch et al., 2003), photolysis (Jamrógiewicz and Wielgomas, 2013) and solar photocatalysis (Radjenović et al., 2010).
Ranitidine abatement in chemically activated persulfate systems: Assessment of industrial iron waste for sustainable applications
2016, Chemical Engineering Journal