Journal of Lipid Mediators and Cell Signalling
Research paperPlatelet-activating factor and cardiac diseases: therapeutic potential for PAF inhibitors
References (183)
- et al.
Age-related effects of platelet activating factor (PAF) in the isolated perfused rat heart
J. Mol. Cell Cardiol.
(1992) - et al.
Platelet-activating factor (PAF) induces platele/'neutrophil co-operation during myocardial reprofusion
J Mol. Cell Cardiol.
(1992) - et al.
Pharmacological modification of thromboxane and prostaglandin release in cardiac anaphylaxis
Prostaglandins
(1978) - et al.
The potential for platelet-activating factor synthesis in brain: Properties of cholinephosphotransferase and 1-alkyl-sn-glycero-3-phosphate acetyltransferase in microsomal fractions of immature rabbit cerebral cortex
Biochim. Biophys. Acta Lipids Lipid Metab
(1993) - et al.
The effects of PAF-acether on the cardiovascular system and their inhibition by a new highly specific PAF-acether receptor antagonist BN 52021
Pharmacol. Res. Commun.
(1986) - et al.
PAF effects 0n eicosanoid release in neonetal rat cardiomyocytes. Prostaglandins Leukotrienes Essent
Fatty Acids
(1995) - et al.
Acute circulatory collapse caused by platelet-activating factor (PAF-acether) in dogs
Eur. J. Pharmacol.
(1983) - et al.
Lipoxygenase products of arachidonic acid modulate biosynthesis of platelet-activating factor (1-0-alkyl-2-acetyl-sn-glycero-3- phosphocholine) by human neutrophils via phospholipase A2
J. Biol. Chem.
(1985) - et al.
Platelet-activating factor and cellular immune response
Immunol. Today
(1987) - et al.
Is there a case for PAF antagonists in the treatment of ischemic states?
TIPS
(1989)
The anoxic rat-heart myocyte produces and releases plateletactivating (PAF) as a component of its ischemia-like pathology
J. Mol. Cell. Cardiol.
Effect of prostacyclin on platelet-activating factor induced rabbit platelet aggregation
Prostaglandins
Cardiac and coronary consequences of intracoronary platelet activating factor infusion in the domestic pig
Prostaglandin
The causal role of PAF and leukotrienes in acute cardiac allograft rejection in rats
Pharmacol. Res. Comm.
Coronary and pulmonary vascular effects of leukotrienes and PAF-acether
Pharmacol. Res. Commun.
Enhanced production of platelet-activating factor in stimulated rat leukocytes pretreated with triacsin C, a novel acyl-CoA synthetase inhibitor
Biochem. Biophys. Res. Commun.
Stimulation of platelet-activating factor synthesis in human endothelial cells by activation of the de novo pathway. Phorbol l2-myristate 13-acetate activates I-alkyl-2-lyso-sn-glycery-3-phosphate: acetyl-CoA acetyltransferase and dithiothreitol-insensitive 1-alkyl-2-acetyl-sn-glycerol:CDP-choline cholinephosphotransferase
J. Biol. Chem.
Protein kinase C and cyclic AMP modulate thrombin-induced platelet-activating factor synthesis in human endothelial cells
Biochim. Biophys. Acta Mol. Cell Res.
Hormonal regulation of platelet-activating factor-acetyltransferase activity in rat tissues
Arch. Biochem. Biophys.
Mechanisms of the hypotensive effect of 1-0-octadecyl-2-0-acetyl-glyceryl-3-ohosphorylcholine
Eur. J. Pharmacol.
Study of digoxin as inhibitor of the in vivo effects of acetyl glyceryl ether phosphorylcholine (AGEPC) in mice
Life Sci.
Constriction of canine coronary arteries by platelet activating factor after brief ischemia
Prostaglandins
Effect 0n BN 52021, a specific PAF-acether antagonist, on cardiac anaphylaxis in Langendorff hearts isolated from passively sensitized guinea-pigs
Eur. J. Pharmacol.
BN 52021, a PAF receptor antagonist, protects isolated working rat hearts against arrhythmias induced by ischemia but not reperfusion
Eur. J. Pharmacol.
Renal necrosis and the involvement of a single enzyme of the de novo pathway for the biosynthesis of platelet-activating factor in the rat kidney inner medulla
Biochem. Biophys. Res. Commun.
Calmodulin antagonist inhibits aggregation of human, guinea pig, and rabbit platelets induced with platelet-activating factor
FEBS Lett.
Inhibition of platelet-activating factor does not alter myocardial stunning
J. Mol. Cell Cardiol.
Effect of inhibition of synthesis and receptor antagonism of SRS-A in cardiac anaphylaxis
Br. J. Pharmacol.
Effects of exogenous prostaglandins on the release of leukotriene C4 like activity and on coronary flow in indomethacin-treated anaphylactic guinea-pig hearts
Arch. Pharmacol.
The cardiac effects of prostaglandins and their modification by the prostaglandin antagonist N 1064
J. Pharmacol. Exp. Ther.
Thromboxane and prostacyclin release during cardiac immediate hypersensitivity reactions in vitro
J. Pharmacol. Exp. Ther.
Role of platelet-activating factor (PAF) in oxygen radical-induced cardiac dysfunction
J. Pharmacol. Exp. Ther.
Effect of platelet-activting factor (PAF) on human cardiac muscle
Int. Arch. Allergy Appl. Immunol.
Protective effect of verapamil on the cardiac and circulatory alterations induced by platelet-activating factor
J. Cardiovasc. Pharmacol.
Isolation of platelet-activating factor (PAF) from ischemic baboon myocardium
Increased PMN adherence on endothelial cells after hypoxia: involvement of PAF, CD18/CDIlb, and ICAM-l
Am. J. Physiol.
Platelet activating factor alters receptorcoupled function in the isolated perfused rat heart
J. Surg. Res.
Leukocyte-dependent histamine release from rabbit platelets: the role of IgE, basophils, and platelet-activating factor
J. Exp. Med.
The actions of PAF-acether (platelet-activating factor) on guinea-pig isolated heart preparations
Br. J. Pharmacol.
PAF-acether (platelet-activating factor)
Adv. Prout. Thromb. Leukotriene Res.
BN 52021, a specific PAF receptor antagonist, prevents antigen-induced mediator release and myocardial changes in guineapig perfused hearts
The ginkgolide BN 52021 protects guineapig from lung and heart anaphylaxis
Inhibition of platelet-activating factor fails to limit ischemia and reperfusion-induced myocardial damage
J. Cardiovasc. Pharmacol.
Circulatory effects of PAFacether in the newborn piglets
Am. J. Physiol.
Perspectives in platelet-activating factor research
Pharmacol. Rev.
BN 52021 and related compounds: a new series of highly specific PAF-acether receptor antagonists
Prostaglandins
Cellular origin of PAF
Isolated cardiac myocytes are sensitized by hypoxia-reoxygenation to neutrophil released mediators
Am. J. Physiol.
Platelet-activating factor increases lung vascular permeability to protein
J. Appl. Physiol.
Effect of plateletactivating factor on guinea-pig papillary muscle
Experientia
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Mechanisms underlying fat pad remodeling induced by fasting: role of PAF receptor
2020, NutritionCitation Excerpt :The stimulation of PAFR triggers the synthesis of inflammatory cytokines [21,22]. Several studies have suggested the role of PAF in a variety of experimental models, such as allergy, inflammation, cardiovascular diseases, and neural systems [25,36–38]. More recently, our group and others have shown that PAF signaling is also an important mediator to control the metabolism, thermogenesis, and adipose tissue function [10,36,39].
Pharmacokinetic studies of ginkgolide K in rat plasma and tissues after intravenous administration using ultra-high performance liquid chromatography-tandem mass spectrometry
2015, Journal of Chromatography B: Analytical Technologies in the Biomedical and Life SciencesCitation Excerpt :Platelet activate factor (PAF) plays a key role in etiology of many diseases such as asthma, neuronal damage, migraine, cardiac diseases, inflammatory, headache, etc. [1–5].
The role of platelet-activating factor in mesangial pathophysiology
2015, American Journal of PathologyCitation Excerpt :As a matter of fact, the term platelet-activating factor is a misnomer, because the effect of PAF on physiologic processes is not limited to and goes far beyond degranulation of platelets, the first effect that was documented.1,6,7 Diverse biological activities are ascribed to PAF, and it was found to be involved in the pathogenesis of a wide range of diseases.8–10 In addition to the effects of the structural variation, the broad spectrum of PAF effects is achieved through a broad range of downstream mediators (Figure 2), via which PAF can elicit many of the reactions of inflammation and allergy, including enhanced leukocyte adhesion, chemotaxis, leukocyte degranulation, respiratory burst, and increased vascular permeability.11–13
Kounis syndrome (allergic angina and allergic myocardial infarction): A natural paradigm?
2006, International Journal of CardiologySynergistic interaction of endogenous platelet-activating factor and vasopressin in generating angina in rats
2004, European Journal of PharmacologyAlterations in myocardial lipid metabolism during myocardial ischemia and reperfusion
2002, Progress in Lipid Research