Elsevier

European Journal of Cancer

Volume 28, Issues 2–3, February–March 1992, Pages 318-321
European Journal of Cancer

Paper
Tamoxifen up-regulates c-erbB-2 expression in oestrogen-responsive breast cancer cells in vitro

https://doi.org/10.1016/S0959-8049(05)80045-0Get rights and content

Expression of the c-erbB-2 proto-oncogene is inhibited by oestrogens in oestrogen-responsive human breast cancer cells, at both mRNA and protein level. Here we report that, where the regulation of c-erbB-2 is concerned, tamoxifen displays a full anti-oestrogenic activity, enhancing the expression of c-erbB-2 in oestrogen receptor-positive cells cultured with untreated fetal calf serum or reversing the inhibitory effect of added oestrogens. Meanwhile, tamoxifen strongly inhibited cell growth. Tamoxifen was inactive on both c-erbB-2 expression and growth of oestrogen receptor-negative cells. These results may have important implications to explain occasional failure of tamoxifen therapy in oestrogen receptor-positive breast cancers.

References (24)

  • GullickWJ et al.

    Expression of the c-erbB-2 protein in normal and transformed cells

    Int J Cancer

    (1987)
  • FortP et al.

    Various rat adult tissues express only one major mRNA species from the glyceraldehyde-3-phosphate-dehydrogenase multigenic family

    Nucleic Acids Res

    (1985)
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