The Journal of Steroid Biochemistry and Molecular Biology
Differential expression of uterine progesterone receptor forms A and B during the menstrual cycle
References (41)
Gene regulation by steroid hormones
Cell
(1989)- et al.
The rabbit progesterone receptor: evidence for a single steroid-binding subunit and characterization of receptor mRNA
J. Biol. Chem.
(1984) - et al.
Progesterone regulates the murine multidrug resistance mdr lb gene
J. Biol. Chem.
(1993) - et al.
Differential effect of forms A and B of the human progesterone receptor on estradiol-dependent transcription
J. Biol. Chem.
(1994) - et al.
RU486 exerts antiestrogenic activities through a novel progesterone receptor A form-mediated mechanism
J. Biol. Chem.
(1994) - et al.
The human progesterone receptor A-form functions as a transcriptional modulator of mineralocorticoid receptor transcriptional activity
J. Steroid Biochem. Molec. Biol.
(1994) - et al.
The A and B forms of a chicken progesterone receptor arise by alternate initiation of trnaslation of the unique mRNA
Biochem. Biophys. Res. Commun.
(1987) - et al.
Transient expression of human and chicken progesterone receptors does not support alternative transitional initiation from a single mRNA as the mechanism generating two receptor isoforms
J. Biol. Chem.
(1990) - et al.
Murine progesterone receptor exists predominantly as the 83-kilodalton ‘A’ form
J. Steroid Biochem. Molec. Biol.
(1991) - et al.
Expression of cadherins and integrins in human endometrium throughout the menstrual cycle
Fertil. and Steril.
(1995)
Oestrogen-induced progesterone receptor in human uterus
J. Steroid Biochem.
Is a functional estrogen receptor always required for progesterone receptor induction in breast cancer?
J. Steroid Biochem.
Progestin regulation of cellular proliferation
Endocrinol. Rev.
Molecular mechanisms of action of steroid/thyroid receptor superfamily members
Ann. Rev. Biochem.
In situ photo linked nuclear progesterone receptors of human breast cancer cells: subunit molecular weights after transformation and translocation
Endocrinol.
Seasonal changes in the molecular species and nuclear binding of the chicken oviduct progesterone receptor
Biochem.
Developmental regulation of murine mammary progesterone receptor gene expression
Endocrinol.
Antagonist-occupied human progesterone B-receptors activate transcription without binding to progesterone response elements and are dominantly inhibited by A-receptors
Mol. Endocrinol.
Inhibitory cross-talk between steroid hormone receptors: differential targeting of estrogen receptor in the repression of its transcriptional activity by agonist- and antagonist-occupied progestin receptors
Mol. Cell. Biol.
Human progesterone receptor A form is a cell- and promoter-specific repressor of human progesterone receptor B function
Mol. Endocrinol.
Cited by (115)
Be quick about it. Endogenous estradiol level, menstrual cycle phase and trait impulsiveness predict impulsive choice in the context of reward acquisition
2015, Hormones and BehaviorCitation Excerpt :Yet, the present data also show that in the state of heightened E2 (i.e., in the late FP) this hormone–behavior relationship no longer existed, despite a constant PROG level across the follicular phase. This might be explained by other factors like cycle-dependent changes in steroid receptor architecture (Mangal et al., 1997). Further, the actual relationship between E2 and behavioral impulsivity could be non-linear and might be similar to the inverted U-function that has been demonstrated previously for the twofold association of mesolimbic DA and impulsivity (Cools et al., 2009; Smith and Boettiger, 2012).
Human Oviduct and Endometrium: Changes over the Menstrual Cycle
2015, Knobil and Neill's Physiology of Reproduction: Two-Volume SetSteroid Hormone Action
2013, Yen and Jaffe's Reproductive Endocrinology: Seventh EditionProgesterone receptor targeting with radiolabelled steroids: An approach in predicting breast cancer response to therapy
2013, Journal of Steroid Biochemistry and Molecular BiologyCitation Excerpt :These nuclear receptors, which specifically bind progesterone and are induced by estrogens, were initially characterized in the mammalian uterus and chick oviduct in the early 1970s, by Sherman [53–56]. PR is expressed in the female reproductive tract, mammary gland, brain, and pituitary gland [57,58]. In many cells estrogens induce expression of PR, and its presence is a common marker for oestrogen action in both research and clinical settings.
Differential regulation of endogenous pro-inflammatory cytokine genes by medroxyprogesterone acetate and norethisterone acetate in cell lines of the female genital tract
2011, ContraceptionCitation Excerpt :We were unable to detect the PR-B isoform in any of the cell lines, and thus we postulate that it is the transcriptionally less active PR-A isoform that is present in these cell lines. Indeed, variation in the expression of PR-A and PR-B has previously been reported in the eutopic endometrium during the menstrual cycle [73], with no PR-B detectable during the secretory and early proliferative phases. Similarly, Attia et al. [74] did not detect any PR-B protein in endometriotic tissue and they ascribe the clinically observed resistance of endometriosis to treatment with progestins to this absence of PR-B and to the presence of PR-A.
Molecular mechanisms of steroid receptor-mediated actions by synthetic progestins used in HRT and contraception
2011, SteroidsCitation Excerpt :Thus although all steroid receptors generally appear to function by similar mechanisms, the progestin-specific intracellular actions on target genes via steroid receptors may vary depending of many factors such as those discussed above. The physiological response of a cell to Prog is mediated by the PR, which is expressed in the female reproductive tract, mammary gland, brain, as well as the pituitary gland [131,132]. Prog plays a central role in various reproductive events associated with establishment and maintenance of pregnancy, normal mammary gland development and sexual behaviour [133,134].
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