7-Silylcamptothecins (silatecans): A new family of camptothecin antitumor agents

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Abstract

The synthesis and biological evaluation of about one dozen 7-silylcamptothecin derivatives are described. Most new compounds show potencies comparable to or better than camptothecin itself. The best compound, 11-fluoro-10-amino-7-trimethylsilylcamptothecin, is more than 20 times more potent than camptothecin in cell assays.

The synthesis and biologic evaluation of a highly active new family of camptothecin analogs is reported.

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