Current Biology
Volume 6, Issue 2, February 1996, Pages 211-212
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Brief communication
A new family of regulators of G-protein-coupled receptors?

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Abstract

Organisms as diverse as fungi and humans use G-protein-coupled receptors to control signal transduction pathways responsive to various hormones, neuroregulatory molecules and other sensory stimuli [1]. Continual stimulation of these receptors often leads to their desensitization, which is mediated in part by the consecutive actions of two families of proteins – the G-protein-coupled receptor kinases, which phosphorylate the agonist-occupied receptors [2], and the arrestin proteins, which subsequently bind to the receptors [3]. We now present evidence that a group of proteins – the G0S8/Sst2p family – may be a third class of receptor-desensitizing factors.

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David P. Siderovski (corresponding author), Quantitative Biology Laboratory, Amgen Institute, 620 University Avenue, Toronto, Ontario, M5G 2C1, Canada. E-mail: [email protected]

Andrew Hessel, Stephen Chung and Tak W. Mak, Quantitative Biology Laboratory, Amgen Institute, 620 University Avenue, Toronto, Ontario, M5G 2C1, Canada.

Michael Tyers, Samuel Lunenfeld Research Institute, Mount Sinai Hospital and Department of Molecular and Medical Genetics, University of Toronto, Toronto, Ontario M5G 1X6, Canada.