Transcriptional regulation: SWItching circuitry

doi:10.1016/S0960-9822(99)80134-1

Current Biology

Volume 9, Issue 6, 25 March 1999, Pages R221-R224

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Abstract

Proteins of the SWI/SNF family disrupt chromatin, hydrolysing ATP in the process. How they do so is still mysterious, but recent studies indicate that they can be targeted to the nuclear infrastructure and to particular genes, where they cooperate with other enzymes to activate or repress transcription.

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PA Wade and AP Wolffe, Laboratory of Molecular Embryology, National Institute of Child Heath and Human Development, NIH, Building 18T, Room 106, Bethesda, Maryland 20892-5431, USA.

E-mail address for PA Wade: [email protected].

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Transcriptional regulation: SWItching circuitry