Review
Tailoring cAMP-signalling responses through isoform multiplicity

https://doi.org/10.1016/S0968-0004(97)01050-5Get rights and content

Abstract

Multiple forms of cAMP phosphodiesterases (PDE), adenylate cyclase and protein kinase A (PKA) allow cells to tailor the responsiveness of the cAMP-signalling system and to allow for its dynamic adjustment. Multiple forms of these enzymes confer spatial and temporal characteristics on cAMP signalling so as to affect compartmentalised responses within a single cell type. The ability to breach the PKA activation threshold can depend upon either or both the activation of adenylate cyclase and inhibition of specific PDE isoforms.

References (49)

  • J.J. Cali et al.

    J. Biol. Chem.

    (1996)
  • R. Taussig et al.

    J. Biol. Chem.

    (1995)
  • G. Bolger

    Cell. Signal.

    (1994)
  • V.C. Manganiello

    Arch. Biochem. Biophys.

    (1995)
  • J.P. Pieroni

    J. Biol. Chem.

    (1995)
  • M.D. Houslay

    Cell. Signal.

    (1990)
  • M.C. Faux et al.

    Cell

    (1996)
  • T.M. Klauck et al.

    Cell. Signal.

    (1995)
  • K.J. Smith

    J. Biol. Chem.

    (1996)
  • G. Bolger et al.

    J. Biol. Chem.

    (1996)
  • E. Huston

    J. Biol. Chem.

    (1996)
  • T. Muller et al.

    Trends Pharmacol. Sci.

    (1996)
  • C. Yan et al.

    J. Biol. Chem.

    (1996)
  • K.A. Fagan et al.

    J. Biol. Chem.

    (1996)
  • H. Aass et al.

    J. Mol. Cell. Cardiol.

    (1988)
  • M.J. Lohse

    Biochim. Biophys. Acta

    (1993)
  • T.J. Torphy

    J. Biol. Chem.

    (1995)
  • C. Sette et al.

    J. Biol. Chem.

    (1996)
  • R.K. Sunahara et al.

    Annu. Rev. Pharmacol. Toxicol.

    (1996)
  • G. Zhang et al.

    Nature

    (1997)
  • J.A. Beavo

    Physiol. Rev.

    (1995)
  • M. Conti et al.

    Endocr. Rev.

    (1995)
  • E.J. Adie et al.

    Biochem. J.

    (1994)
  • D.J. MacEwan et al.

    Mol. Pharmacol.

    (1995)

    • Cited by (0)

    View full text
    Copyright © 1997 Published by Elsevier Ltd.