Brief reviewsRegulators of G-protein Signaling in Receptor Complexes☆
Section snippets
Acknowledgements
We thank Deepak Shrivastava for comments on the manuscript and our colleagues for stimulating discussions. We referenced reviews, rather than many of the primary papers, owing to space limitations. TMW is an Established Investigator of the American Heart Association.
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RGS/G<inf>i2α</inf> interactions modulate platelet accumulation and thrombus formation at sites of vascular injury
2010, BloodCitation Excerpt :In general, G proteins remain active until hydrolysis of Gα-bound guanosine-5′-triphosphate (GTP) restores the resting state. The rate of inactivation is determined in part by members of the regulators of G-protein signaling (RGS) family, which accelerate GTP hydrolysis by Gα.1-4 The 37 known RGS proteins have a 120 amino acid RGS domain that can interact with the switch region of activated Gα.5,6
Cellular mechanisms that determine selective RGS protein regulation of G protein-coupled receptor signaling
2006, Seminars in Cell and Developmental Biology
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