ArticleImpaired Vasodilator Function in Hypertension: The Role of Alterations in Receptor–G Protein Coupling
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2014, Canadian Journal of CardiologyCitation Excerpt :Similarly, regulation of vasodilator forces is mediated by an overlapping set of GPCR-activating hormones, including adenosine, glucagon, serotonin (through 5-hydroxytryptamine 1 receptors), calcitonin gene-related peptide, vasopressin, vasoactive intestinal peptide, prostanoids, dopamine (through D1 and D5 receptors), histamine (through H2 receptors), and bradykinin. Overall, in hypertension the balance is shifted toward enhanced vasoconstrictor forces.49 Hyper-responsiveness of some vasoconstrictor systems has been reported in hypertensive models.
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2012, Trends in Cardiovascular MedicineCitation Excerpt :Impaired GPCR signaling in the vasculature has a dramatic impact on overall cardiovascular health. Disruption of β2-AR–mediated vasodilation, accompanied by vascular GRK2 upregulation, has been implicated in hypertension in both human patients and animal models (Cohn et al. 2008, Cohn et al. 2009, Eckhart et al. 2002, Feldman 1990, Feldman and Gros 1998, Gros et al. 2000, Izzo et al. 2008). Interestingly, the properties of β-ARs in human lymphocytes mirror the changes observed in β-ARs from less accessible tissues, allowing clinicians to utilize lymphocytes as valuable tools for the assessment of β-AR function both in hypertension and in HF (Bonita et al. 2010, Hata et al. 2006, Oyama et al. 2006).
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