Chemistry & Biology
Volume 9, Issue 12, December 2002, Pages 1275-1285
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Review
Small Molecules, Big Impact: A History of Chemical Inhibitors and the Cytoskeleton

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Abstract

Chemical inhibitors, whether natural products or synthetic, have had an enormous impact on the study of the eukaryotic cytoskeleton. Here we review the history of some of the most widely used cytoskeletal poisons and their influence on our understanding of cytoskeletal functions. We then highlight several new inhibitors and the targeted screens used to identify them and discuss why this approach has been successful.

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