Molecular effects of dopamine on striatal-projection pathways

doi:10.1016/S1471-1931(00)00019-7

Trends in Neurosciences

Volume 23, Supplement 1, October 2000, Pages S64-S70

https://doi.org/10.1016/S1471-1931(00)00019-7 Get rights and content

Gene regulation studies demonstrate that dopamine differentially regulates the direct and indirect projection neurons of the striatum through their respective expression of the D1 and D2 dopamine receptors. Induction of immediate-early genes (IEGs) in striatal neurons is used to study dopaminereceptor-mediated neuronal plasticity. In the dopamine-depleted striatum there is a switch in receptor-mediated signal transduction mechanisms to produce a supersensitive form of D1- mediated neuronal plasticity. This switch is suggested to underlie dopamine-agonist-induced dyskinetic movements that develop during the treatment of Parkinson's disease.

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Trends in Neurosciences

ReviewMolecular effects of dopamine on striatal-projection pathways

Trends Neurosci.

Trends Neurosci.

Trends Neurosci.

Brain Res.

Neurol. Clin.

Neuron

Neuron

Brain Res.

Neuroscience

Neuroscience

Neuron

Trends Neurosci.

D1 and D2 dopamine receptor-regulated gene expression of striatonigral and striatopallidal neurons

Science

Projection subtypes of rat neostriatal matrix cells revealed by intracellular injection of biocytin

J. Neurosci.

A basal ganglia pacemaker formed by the subthalamic nucleus and external globus pallidus

Nature

Primate globus pallidus and subthalamic nucleus: functional organization

J. Neurophysiol.

Visual and oculomotor functions of monkey substantia nigra pars reticulata. I. Relation of visual and auditory responses to saccades

J. Neurophysiol.

Basal ganglia motor control. I. Nonexclusive relation of pallidal discharge to five movement modes

J. Neurophysiol.

Basal ganglia motor control. II. Late pallidal timing relative to movement onset and inconsistent pallidal coding of movement parameters

J. Neurophysiol.

Ratio of inhibited-to-activated pallidal neurons decreases dramatically during passive limb movement in the MPTP-treated monkey

J. Neurophysiol.

Pathophysiology of levodopa-induced dyskinesias in Parkinson's disease: problems with the current model

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Localization of D1 and D2 dopamine receptors in brain with subtype-specific antibodies

Multiple receptors for dopamine

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Opposing roles for D-1 and D-2 dopamine receptors in efflux of cyclic AMP from rat neostriatum

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Mesencephalic dopamine neurons regulate the expression of neuropeptide mRNAs in the rat forebrain

Review
Molecular effects of dopamine on striatal-projection pathways