Developmental Cell
Volume 4, Issue 5, May 2003, Pages 607-608
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Nuclear Receptors Orchestrate Detoxification Pathways

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Abstract

Two nuclear receptors of xenobiotic drugs, PXR and CAR, are central regulators of detoxification enzymes. New studies extend the role of these receptors to a natural detoxification process. They coordinate induction of proteins for storage, glucuronidation, and canalicular transport of bilirubin.

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