Developmental Cell
Volume 5, Issue 2, August 2003, Pages 351-358
Journal home page for Developmental Cell

Short article
Embryonic Stem Cell-Specific MicroRNAs

https://doi.org/10.1016/S1534-5807(03)00227-2Get rights and content
Under an Elsevier user license
open archive

Abstract

We have identified microRNAs (miRNAs) in undifferentiated and differentiated mouse embryonic stem (ES) cells. Some of these appear to be ES cell specific, have related sequences, and are encoded by genomic loci clustered within 2.2 kb of each other. Their expression is repressed as ES cells differentiate into embryoid bodies and is undetectable in adult mouse organs. In contrast, the levels of many previously described miRNAs remain constant or increase upon differentiation. Our results suggest that miRNAs may have a role in the maintenance of the pluripotent cell state and in the regulation of early mammalian development.

Cited by (0)