Lessons from patient-derived xenografts for better in vitro modeling of human cancer☆,☆☆
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open access
Graphical abstract
Keywords
Patient-derived xenografts
Acidic tumor microenvironment
Cancer–stromal interactions
Extracellular matrix
Tumor heterogeneity
Cancer-associated fibroblasts
Regulatory immune cells
Acidic culture conditions
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This review is part of the Advanced Drug Delivery Reviews theme issue on “Engineering of Tumor Microenvironments”.
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Grant support: This study was supported in part by the Canadian Institutes of Health Research (YZW) (IPR-119991 and MOP-123449), Terry Fox Research Institute (YZW), BC Cancer Foundation (YZW), and Prostate Cancer Canada (CCC, YZW). YZW is a recipient of an award from the Tianjin Thousand Talents Program. SYCC is a recipient of a CIHR Frederick Banting and Charles Best Master's Award and a CIHR Doctoral Award.
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The authors contributed equally to this work.
Copyright © 2014 The Authors. Published by Elsevier B.V.