Clinical research studyAnalgesic Use and the Risk of Hearing Loss in Men
Section snippets
Participants
The Health Professionals Follow-up Study originally enrolled 51,529 male dentists, optometrists, osteopaths, pharmacists, podiatrists, and veterinarians who were 40-75 years of age at baseline in 1986. Study participants filled out detailed questionnaires about diet, medical history, and medication use. These questionnaires have been administered every other year, and the 20-year follow-up exceeds 90%. The 2004 long-form questionnaire included a question about whether the participant had been
Results
Characteristics of participants at baseline according to analgesic use are shown in Table 1. Although updated information was used for the analysis, characteristics are presented from baseline to provide representative values. Regular aspirin and NSAID users were older and acetaminophen users were younger than nonregular users. Hypertension was more common among regular analgesic users. It was common for an individual to use more than one type of analgesic regularly.
During 369,079 person-years
Discussion
Regular analgesic use was independently associated with an increased risk of hearing loss. The increased risk of hearing loss seen with regular analgesic use was greatest among younger men, particularly those below age 60 years. In men aged 60 years and above, there was no relation observed between the risk of hearing loss and regular aspirin use, and the relation between regular use of NSAIDs and acetaminophen was attenuated. The risk of hearing loss increased with longer duration of analgesic
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Cited by (73)
Sex differences in the auditory functions of rodents
2022, Hearing ResearchCitation Excerpt :In fact, recent studies reported that females experienced limited benefits from hearing aids and benefited from tinnitus treatments differently than males (Van der Wal, Luyten and Cardon, 2020). Epidemiological studies have associated aspirin use with hearing loss in men but not in women (Curhan, Eavey, Shargorodsky and Curhan, 2010). Moreover, a cross-sectional study observed higher incidence of developing ototoxicity in men than in women treated for multidrug resistant Mycobacterium tuberculosis (Javadi et al., 2011).
Expression of drug metabolizing enzymes and transporters in the cochlea: Implications for drug delivery and ototoxicity
2019, Hearing ResearchCitation Excerpt :Recently, several groups have reported evidence that long-term therapeutic use of analgesics, including APAP and NSAIDs, is associated with hearing problems. Data from numerous epidemiological studies indicate that use of those drugs modestly but significantly increases risk of premature hearing loss (Curhan et al., 2010, 2012; Kyle et al., 2015; Lin et al., 2017). Furthermore, there have been nearly 30 reports of serious ototoxicity resulting in deafness after therapeutic use or abuse of APAP/opioid combination products (McGill et al., 2016), and both in vitro and in vivo studies have provided a possible mechanistic basis (Yorgason et al., 2010; Kalinec et al., 2014; McGill et al., 2016).
Longitudinal study of hearing loss and subjective cognitive function decline in men
2019, Alzheimer's and DementiaTraditional oriental medicine for sensorineural hearing loss: Can ethnopharmacology contribute to potential drug discovery?
2019, Journal of EthnopharmacologyCitation Excerpt :Other external factors, including occupational noise, certain drugs, and exposure to heavy metals, are also considered ototoxic agents (Choi and Kim, 2014). Epidemiological studies have shown that regular use of some drugs is associated with an increased risk of auditory cell damage, including nonsteroidal anti-inflammatory drugs, loop diuretics, chemotherapeutic agents, antimalarics, macrolides, glycopeptides, and aminoglycosides (Curhan et al., 2010; Eiamprapai et al., 2012; Javadi et al., 2011). Metabolic disorders, such as diabetes and hypertension, are also associated with a reduction in cochlear microcirculation and with damage to neural structures.
Age-related hearing loss: An updated and comprehensive review of the interventions
2024, Iranian Journal of Basic Medical Sciences
Funding: This work was supported by National Institutes of Health grant P01 CA055075 and the Massachusetts Eye and Ear Infirmary Foundation, Boston, Mass.
The sponsors of the study had no role in study design, data collection, data analysis, data interpretation, or writing of the report. The corresponding author had full access to all the data in the study and had final responsibility for the decision to submit for publication.
Conflict of Interest: The authors have no conflicts of interest to report.
Authorship: All authors had access to the data and a role in writing the manuscript.