Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease
Volume 1832, Issue 7, July 2013, Pages 989-997
ReviewMacrophages and fibrosis: How resident and infiltrating mononuclear phagocytes orchestrate all phases of tissue injury and repair☆
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Highlights
► Fibrosis was selected throughout evolution because of its life saving benefits. ► Macrophages contribute to fibrosis because they contribute to all phases of tissue injury and repair. ► Macrophages not only support fibrogenesis, but they also support fibrolysis. ► Suppressing sterile tissue inflammation and promoting tissue regeneration are the best way to prevent tissue fibrosis.
Keywords
Immunity
Regeneration
Polarization
Inflammation
Wound healing
Fibrosis
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This article is part of a Special Issue entitled: Fibrosis: Translation of basic research to human disease.
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