Original article3,4-Methylenedioxymethamphetamine in Adult Rats Produces Deficits in Path Integration and Spatial Reference Memory
Section snippets
Subjects
Male Sprague-Dawley rats (225–250 g) were obtained from Charles River Laboratories (Raleigh, North Carolina). The rats were allowed to acclimate to the colony room for 1 week prior to the day of drug administration. The colony room was maintained at a temperature of 21°C to 22°C with food and water available ad libitum. The animals were initially housed in pairs in cages measuring 45.7 x 23.8 x 20.3 cm prior to drug administration, then singly during and following drug administration. For the
Temperature Monitoring
Both the SAL- and MDMA-treated animals began the experiment with comparable body temperatures. There was a significant main effect of treatment, F(1,34) = 43.11, p < .0001; time, F(20,680) = 5.89, p < .0001; and the interaction of treatment x time, F(20,680) = 15.89, p < .0001. Analysis of the interaction showed that following the first injection, body temperatures of the MDMA-treated animals steadily increased, and at 90 minutes, temperatures were significantly increased relative to
Discussion
The major new finding within this set of experiments was that MDMA-treated animals committed more errors in the CWM than control subjects. Cincinnati water maze requires a path integration strategy for finding the goal, as opposed to the MWM, where an animal relies on the use of spatial cues to navigate through its environment (Morris et al 1982). Path integration involves the use of both allothetic (external) and idiothetic (internal) cues (Whishaw et al 2001). Idiothetic cues may be visual,
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