Original articleAgomelatine, a New Antidepressant, Induces Regional Changes in Hippocampal Neurogenesis
Section snippets
Animals
Adult 8-week-old male Wistar rats (220–240 g; Iffa Credo, l’Arbresles, France) were group-housed (three per cage) in a temperature-controlled room (21°C) and maintained on a 12-hour light/dark cycle with free access to food and water. This study was carried out in accordance with the French Agriculture and Forestry Ministry (decree 87848, license 01498). There were five to seven rats per group.
Treatment
The dose of agomelatine used in the present study was chosen on the basis of its activity in various
Hippocampus
The BrdU-labeled cells are located in the SGZ and frequently associated in clusters shortly after injection (Figure 3A). The total numbers of BrdU-positive cells were not significantly different over time in the acute (4 hours), subchronic (1 week), and chronic (3 weeks) control groups (Figure 4A). Although no effect was observed after 4 hours or 1 week of agomelatine treatment, a tendency toward an increase was observed in 3-week-treated rats (Figure 4A). Then a separate analysis was conducted
Discussion
Agomelatine is a new drug with demonstrated antidepressant activity in both preclinical animal models of depression (Bourin et al 2004, Papp et al 2003) and in patients with major depressive disorders (Loo et al 2002b, Loo et al 2003). Here, we demonstrate that chronic administration of agomelatine increases the absolute number of newly formed granule neurons in the DG of nonstressed rats. Beside the stimulatory effect of agomelatine on cell proliferation and neurogenesis, agomelatine increases
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