Archival ReportEffect of the Novel Positive Allosteric Modulator of Metabotropic Glutamate Receptor 2 AZD8529 on Incubation of Methamphetamine Craving After Prolonged Voluntary Abstinence in a Rat Model
Section snippets
Methods and Materials
See supplement 1 for details on subjects, drugs, intravenous surgery, apparatus, procedures, abstinence phase, extinction tests, and statistical analyses.
Experiment 1: Incubation of Methamphetamine Craving After Short-Term Extended Daily Drug Access
The rats increased their food and methamphetamine intake over sessions (Figure 1A,B), and as in our previous study, extended access (9 hours/day) of methamphetamine led to strong escalation of drug intake (26, 53, 55). The repeated measures analysis of variance showed a significant effect of session for both food (F5,100 = 3.5, p < .01) and methamphetamine (F11,220 = 37.5, p < .001). During the three discrete choice sessions, the rats showed a strong preference for the food (p < .01, Figure 1C).
Discussion
There are two main findings in our study. First, time-dependent increases in cue-induced methamphetamine seeking (incubation of methamphetamine craving) were reliably observed after prolonged periods of choice-based voluntary abstinence. This effect was observed under two different self-administration procedures that are widely used to model drug addiction: extended daily access drug self-administration procedure (40, 41) and a long-term training procedure used to identify addicted rats based
Acknowledgments and Disclosures
This research was supported by the National Institute on Drug Abuse, Intramural Research Program funds (YS and GS). NJM received support from Early Career Fellowship 1053308 by the National Health and Medical Research Council.
DC, MV, TZ, XL, SA, RM, NJM, FL, and JMB carried out the experiments; DC, MV, and YS performed data analysis. DC, GS, FL, and YS designed the study and wrote the manuscript with MV. All authors critically reviewed the content and approved the final version before
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