Discovery of non-peptidergic MrgX1 and MrgX2 receptor agonists and exploration of an initial SAR using solid-phase synthesis
Graphical abstract
A class of small molecules displaying comparable activities with peptide ligands BAM22 and corticostatin-14 at both the human and rhesus monkey MrgX1 and MrgX2, respectively, receptors was discovered.
Section snippets
Acknowledgment
We thank Mrs. Sine Mandrup Bertozzi for analytical assistance.
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