Synthesis and in vivo evaluation of 3,4-disubstituted gababutins
Graphical abstract
A range of 3,4-disubstituted gababutins were synthesised and, of these, the stand-out compound was (21). This compound was profiled in in vivo models of pain and anxiety.
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Acknowledgements
We would like to thank Jane McGuffog for GC/HPLC analysis and Giles Ratcliffe for NMR studies.
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