EditorialProteases in Irritable Bowel Syndrome: A Lot More Than Just Digestive Enzymes
Section snippets
Acknowledgements
I thank Drs R. De Giorgio and C. Cremon (University of Bologna, Italy) for helpful discussions.
References (23)
- et al.
AGA technical review on irritable bowel syndrome
Gastroenterology
(2002) - et al.
Molecular defects in mucosal serotonin content and decreased serotonin reuptake transporter in ulcerative colitis and irritable bowel syndrome
Gastroenterology
(2004) - et al.
Alterations in expression of p11 and SERT in mucosal biopsy specimens of patients with irritable bowel syndrome
Gastroenterology
(2007) - et al.
Eradication of small intestinal bacterial overgrowth reduces symptoms of irritable bowel syndrome
Am J Gastroenterol
(2000) Postinfectious irritable bowel syndrome
Gastroenterology
(2003)- et al.
Fecal serine-protease activity: a pathophysiological factor in diarrhea-predominant irritable bowel syndrome—a pilot study
Clin Gastroenterol Hepatol
(2007) - et al.
Proteinases and proteinase-activated receptor 2: a possible role to promote visceral hyperalgesia in rats
Gastroenterology
(2002) - et al.
Induction of intestinal inflammation in mouse by activation of proteinase-activated receptor-2
Am J Pathol
(2002) - et al.
Activated mast cells in proximity to colonic nerves correlate with abdominal pain in irritable bowel syndrome
Gastroenterology
(2004) - et al.
Mast cell-dependent excitation of visceral-nociceptive sensory neurons in irritable bowel syndrome
Gastroenterology
(2007)
Cited by (6)
Emerging Role of the Gut Microbiome in Irritable Bowel Syndrome
2021, Gastroenterology Clinics of North AmericaCitation Excerpt :This finding suggests fecal LPS plays a key role in VH induced by a high-FODMAP diet in patients with IBS-D. However, it is not clear whether this effect by LPS is mediated via direct stimulation of TLR4 receptor on enteric neurons or indirectly via activation of TLR4 receptors on mast cells (or other immune cells). Fecal as well as mucosal proteolytic activity has been shown to be increased in patients with IBS-D.74 However, it is not clear whether this increased proteolytic activity is derived from host and/or the microbiome. In a recent study, transplant of GF mice with feces from patients with IBS-D with high fecal proteolytic activity led to ineffective inhibition or, in some cases, an increase in fecal proteolytic activity compared with GF state.57
The relationship between gut microbiota and proteolytic activity in irritable bowel syndrome
2021, Microbial PathogenesisCitation Excerpt :The primary function of protease in the digestive tract is to decompose various food proteins, especially trypsin, chymotrypsin, and elastase from the pancreas that are crucial for food protein decomposition. Since the discovery of protease-activated receptors (PARs) expression in the gut (endothelial cells of the lamina propria, epithelial cells, smooth muscle cells, enteric neurons, fibroblasts, and on some immune cells), another function of intestinal protease has been clarified: it acts as a signal molecule to regulate a variety of cellular functions [57,58]. Therefore, a key role of proteases in several biological processes is deduced [52], and any abnormality of PA will lead to diseases, such as infection, inflammation, cancer, viral diseases, hemorrhagic diseases, neurodegenerative diseases, cardiovascular diseases, and IBS.
An emerging field: Post-translational modification in microbiome
2023, ProteomicsGut serine proteases and diarrhea-predominant irritable bowel syndrome
2013, Chinese Journal of GastroenterologySubjects with diarrhea-predominant IBS have increased rectal permeability responsive to tryptase
2010, Digestive Diseases and Sciences