Editorial
Proteases in Irritable Bowel Syndrome: A Lot More Than Just Digestive Enzymes

https://doi.org/10.1016/j.cgh.2007.03.001Get rights and content

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Acknowledgements

I thank Drs R. De Giorgio and C. Cremon (University of Bologna, Italy) for helpful discussions.

References (23)

Cited by (6)

  • Emerging Role of the Gut Microbiome in Irritable Bowel Syndrome

    2021, Gastroenterology Clinics of North America
    Citation Excerpt :

    This finding suggests fecal LPS plays a key role in VH induced by a high-FODMAP diet in patients with IBS-D. However, it is not clear whether this effect by LPS is mediated via direct stimulation of TLR4 receptor on enteric neurons or indirectly via activation of TLR4 receptors on mast cells (or other immune cells). Fecal as well as mucosal proteolytic activity has been shown to be increased in patients with IBS-D.74 However, it is not clear whether this increased proteolytic activity is derived from host and/or the microbiome. In a recent study, transplant of GF mice with feces from patients with IBS-D with high fecal proteolytic activity led to ineffective inhibition or, in some cases, an increase in fecal proteolytic activity compared with GF state.57

  • The relationship between gut microbiota and proteolytic activity in irritable bowel syndrome

    2021, Microbial Pathogenesis
    Citation Excerpt :

    The primary function of protease in the digestive tract is to decompose various food proteins, especially trypsin, chymotrypsin, and elastase from the pancreas that are crucial for food protein decomposition. Since the discovery of protease-activated receptors (PARs) expression in the gut (endothelial cells of the lamina propria, epithelial cells, smooth muscle cells, enteric neurons, fibroblasts, and on some immune cells), another function of intestinal protease has been clarified: it acts as a signal molecule to regulate a variety of cellular functions [57,58]. Therefore, a key role of proteases in several biological processes is deduced [52], and any abnormality of PA will lead to diseases, such as infection, inflammation, cancer, viral diseases, hemorrhagic diseases, neurodegenerative diseases, cardiovascular diseases, and IBS.

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