Current Biology
Volume 22, Issue 21, 6 November 2012, Pages 2063-2068
ReportGenetic Deletion of RALA and RALB Small GTPases Reveals Redundant Functions in Development and Tumorigenesis
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Highlights
► Rala is required for embryonic development; Ralb is a nonessential gene ► RALA and RALB act redundantly in early embryogenesis and are important for neurulation ► Loss of both RALA and RALB is incompatible with tumorigenesis ► RAL function is required for cell proliferation, but either RALA or RALB is sufficient
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