Immunity
Volume 28, Issue 1, 18 January 2008, Pages 1-4
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Commentary
Genetic Background and the Dilemma of Translating Mouse Studies to Humans

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C57BL/6 genetically modified mouse models are the accepted gold standard in biological studies. However, an increasing failure of translating the findings to human (patho)physiology casts doubt on using a single strain to address many questions.

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