Asthma diagnosis and treatmentPlacebo response in asthma: A robust and objective phenomenon
Section snippets
Participants
Subjects were recruited at the National Jewish Medical and Research Center and the University of Iowa. Eligible subjects were men and women, aged 18 to 55 years, with mild intermittent or persistent asthma17 and a baseline FEV1 of 80% of predicted value or greater. Major exclusion criteria included pregnancy or breast-feeding, serious systemic illness, recent respiratory tract infection, use of inhaled corticosteroids or other controller medications within 4 weeks, and smoking (>5 pack-year
Participants
Fifty-five subjects completed the study at 2 sites. Five subjects dropped out after the second screening visit; none were disqualified because of unstable airway hyperresponsiveness. The mean age of participants was 29.7 years (SD, 11.3); women comprised 56.4% of the population, and 91% of the sample was white. Mean BMI was 30.2 (SD, 6.5). There were no significant differences between those assigned to the enhanced and the efficient physician conditions in any demographic, psychologic, or
Discussion
The last decade has seen an increased interest in the placebo response in physical disease, and placebo effects have been documented in numerous conditions.2 Recently, the neural circuitry underlying these effects has begun to be mapped.20 However, the vast majority of studies examine effects in subjectively experienced outcomes, such as pain and depression, suggesting higher-order brain modulation of central processes relevant to these conditions. Relatively little is known about the ability
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Reaction time and working memory in middle-aged gamers and non-gamers
2022, Acta PsychologicaCitation Excerpt :Weimer, Colloca, and Enck (2015) reported that age was found to moderate the strength of the placebo response in 20 of 75 systematic reviews and meta-analyses. For example, Kemeny et al. (2007) showed that responders to a placebo asthma medicine were younger (24.0 years) than non-responders (30.9 years). Similarly, a systematic review (Pitz, Cheang, & Bernstein, 2005) reported lower response rates to a placebo treatment for irritable bowel syndrome with increasing age.
What can be done to control the placebo response in clinical trials? A narrative review
2021, Contemporary Clinical TrialsInhaled peppermint, rosemary and eucalyptus essential oils do not change spirometry in healthy individuals
2018, Physiology and BehaviorMechanisms of placebo analgesia: A dual-process model informed by insights from cross-species comparisons
2018, Progress in Neurobiology
Supported by the Mind, Body, Brain, and Health Initiative and the National Institutes of Health (RR020645, RR00059, and ES05605).
Disclosure of potential conflict of interest: J. N. Kline has consulting arrangements with Critical Therapeutics and Genentech; has received grant support from the National Institutes of Health, Centocor, Genentech, GlaxoSmithKline, and Novartis; and is on the speakers' bureau for Merck, GlaxoSmithKline, Critical Therapeutics, and Genentech. R. A. Panettieri has consulting arrangements with AstraZeneca, AtheroGenics, BioMarck, BioWa, Centocor, Enhanced Pharmaceuticals, Epigenesis, GlaxoSmithKline, Johnson & Johnson, Merck, Sepracor, and Tanox; has received grant support from Centocor, Epigenesis, GlaxoSmithKline, Merck, Prolexys, Novartis, and Sepracor; and is on the speakers' bureau for AstraZeneca, GlaxoSmithKline, Merck, and Novartis. The rest of the authors have declared that they have no conflict of interest.