5-HT2A/2C receptor blockade regulates progenitor cell proliferation in the adult rat hippocampus
Section snippets
Acknowledgement
This work was supported by a Wellcome Trust Senior Fellowship (040082003114133) to V.V.
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2017, Progress in NeurobiologyCitation Excerpt :Furthermore, administration of selective 5-HT2CR agonists increases the number of newly formed neurons in the dentate gyrus (Banasr et al., 2004). In contrast, sustained 5-HT2A/2CR blockade by antagonists (i.e. ketanserin and S32006) results in increased hippocampal progenitor cell proliferation in mice and rats (Jha et al., 2008; Soumier et al., 2009). Another intriguing possible mechanism for 5-HT2R involvement in the regulation of neuronal morphology is through the receptor-mediated control of mitochondrial biogenesis.
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2016, NeuropharmacologyCitation Excerpt :In agreement with the findings in mutant mice, pharmacological studies reported that the acute administration of the 5-HT2A receptor antagonist ketanserin decreased cell proliferation (Banasr et al., 2004; Jha et al., 2008). However, the sustained administration of ketanserin produced opposite effects (Jha et al., 2008) and the fact that atypical antipsychotics, which also display 5-HT2A receptor antagonistic activity, potentiate SSRI-induced hippocampal cell proliferation in animal models of depression (Xu et al., 2006; Wang et al., 2013) contrast with our present data. It is therefore possible that the hypersensitization/upregulation of the 5-HT1A autoreceptor detected in 5-HT2A−/− mice would play a major role in attenuating such SSRI response.
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