Effects of salvinorin A on locomotor sensitization to D2/D3 dopamine agonist quinpirole
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Acknowledgements
We thank Ms. Dawn Graham for her help in carrying out a portion of the study. This study was supported by an operating grant (MOP-64424) from the Canadian Institutes of Health Research.
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2019, Biological PsychiatryCitation Excerpt :Since it was shown that the activity of antipsychotics correlates with their ability to block the D2 receptor (96,97), increased dopamine signaling through postsynaptic striatal D2 receptors that have become sensitized has been hypothesized to play a critical role in the positive symptoms of schizophrenia (98–102). Importantly, while endogenous levels of KOR signaling do not have an effect on locomotor sensitization (73), administration of KOR agonists resulting in supraphysiological levels of KOR signaling during the sensitization period both accelerate and potentiate this process (73,94,95,103,104). Both the acceleration and potentiation of sensitization are relevant to schizophrenia for two reasons.
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2009, PeptidesCitation Excerpt :Acute stimulation of KOR during lactation reduced total locomotion, rearing and grooming, and increased immobility [940]. Low and high doses of salvinorin A respectively potentiated and attenuated the locomotor sensitization to D2/D3 dopamine agonist quinpirole [58]. Dorsal striatal infusions of R(−)-propyinorapomorphine, but not GP or STN lesions, attenuated KOR agonist-induced locomotor activity in the young rat [148].