Effect of the histone deacetylase inhibitors on behavioural sensitization to a single morphine exposure in mice
Graphical abstract
Highlights
► A single morphine-induced behavioural sensitization is simple and convenient. ► Reveal mechanisms of histone acetylation on development of morphine sensitization. ► HDACs in rodents may regulate drug addiction-related behaviours. ► Open a new potential way toward treating drug abuse and dependence.
Section snippets
Acknowledgements
This work was supported by grants from National Nature Science Foundation of China (Nos. 30570653 and 30870894), National Basic Research Program of China (Nos. 2003CB515400 and 2009CB522000), 985 Program of China Ministry of Education (State Key Laboratory of Natural and Biomimetic Drugs, Peking University) and Tianjin Medical University Science Foundation of China (No. 2010ky02). A.J.L. is a Senior Fellow supported by the National Health & Medical Research Council (Australia).
References (31)
- et al.
Epigenetic targets of HDAC inhibition in neurodegenerative and psychiatric disorders
Curr. Opin. Pharmacol.
(2008) - et al.
Valproic acid and other histone deacetylase inhibitors induce microglial apoptosis and attenuate lipopolysaccharide-induced dopaminergic neurotoxicity
Neuroscience
(2007) Inhibition of histone deacetylase activity by butyrate
J. Nutr.
(2003)- et al.
Morphine alleviates early stages of apoptosis in cultured CEM x174 cells infected with simian immunodeficiency virus
Cell Biol. Int.
(2003) A histone deacetylase regulates addiction
Neuron
(2007)- et al.
A single preexposure produces sensitization to the locomotor effects of cocaine in mice
Pharmacol. Biochem. Behav.
(1993) - et al.
Histone deacetylase inhibitors modulates the induction and expression of amphetamine-induced behavioral sensitization partially through an associated learning of the environment in mice
Behav. Brain Res.
(2007) - et al.
Long-term blockade of the expression of cocaine sensitization by ondansetron, a 5-HT(3) receptor antagonist
Eur. J. Pharmacol.
(2000) - et al.
Chromatin remodeling is a key mechanism underlying cocaine-induced plasticity in striatum
Neuron
(2005) Effects of interdose interval on ambulatory sensitization to methamphetamine, cocaine and morphine in mice
Eur. J. Pharmacol.
(1996)