Effects of neonatal and prepubertal hormonal manipulations upon estrogen neuroprotection of the nigrostriatal dopaminergic system within female and male mice
Section snippets
General procedure
Two experiments were performed as part of this report. In experiment 1, the effects of neonatal hormonal manipulations were examined, while the effects of prepubertal hormonal manipulations were performed in experiment 2. The purpose of experiment 1 was to examine whether attempts to masculinize the neonatal female or feminize the neonatal male mouse would alter the sexually dimorphic effects of E to function as a neuroprotectant within the adult. Masculinization of the female was achieved by
Experiment 1
A summary of the data obtained from attempts to masculinize the female mouse with neonatal treatments of T is presented in Fig. 1. Substantial reductions in striatal DA concentrations (Fig. 1A) and increases in DOPAC/DA ratios (Fig. 1B) are observed in MA versus vehicle treated mice demonstrating the neurotoxic effects of this psychostimulant. No statistically significant differences in either striatal DA concentrations or DOPAC/DA ratios were obtained between E- versus non-E-treated mice that
Discussion
The present results reveal some interesting organizational and developmental influences of gonadal steroid hormones upon the capacity for E to function as a neuroprotectant within the adult. The basic premise for this experiment was that a sexually dimorphic difference exists in E's capacity to function as a neuroprotectant and the issue of whether this difference may be attributed to organizational or developmental actions of gonadal steroid hormones was addressed. To this end we attempted to
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2014, Experimental NeurologyCitation Excerpt :All studies using females ovariectomized at 6 weeks showed neuroprotection when 17β-estradiol was administered before the toxin exposure. One study using females ovariectomized before puberty was negative (Anderson et al., 2005) and another study using two year old intact females was negative (Miller et al., 1998). Interestingly, studies using a similar protocol but using the MA toxicity model instead of MPTP showed different results for male and female mice.
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