Trends in Endocrinology & Metabolism
Are XX and XY brain cells intrinsically different?
Section snippets
Sex differences in sex chromosome gene expression
XX and XY cells have a different complement of genes, which might reasonably lead the cells to have intrinsic differences, irrespective of their hormonal environment. First, XY cells have Y-linked genes that are absent in XX cells. The potential impact of Y genes is restricted because the mammalian Y chromosome is gene poor (only 27 different proteins appear to be encoded by the human Y chromosome [10]), and because the expression of several Y genes is limited to a single cell type (male germ
Sex chromosome induction of sex differences in tissues other than the gonads
The information about X and Y gene dosage forms an important foundation for understanding the potential for differences between XX and XY cells that are independent of the hormonal environment. However, the central question is whether these cells differ in form or function because of X and Y gene expression within the cells themselves. One of the first reports suggesting such a difference was that male and female mammalian embryos develop at a different rate at ages before the onset of gonadal
Mouse model systems for varying sex chromosome complement
The field of sex determination, however, has provided mouse model systems that are particularly useful because the genetic sex of cells is made independent of gonadal phenotype. When Sry was identified as the testis-determining gene, it became possible to identify mice that had a Y chromosome lacking Sry (the Y− chromosome) 31, 32, producing XY− mice with a male genome (except for the absence of Sry), but which have ovaries and hence are called females here. Sry has been added back into these
Studies of birds
The unraveling of hormonal and sex chromosome control of sexual differentiation of the zebra finch Taeniopygia guttata brain has been particularly interesting. Male zebra finches sing a courtship song that females cannot sing, and the neural circuit for song is much larger in males [43]. When females are treated with estrogen at hatching, their song regions are permanently masculinized (larger) and they do sing 44, 45. This result suggests that, as in some mammals, the male brain is
Relevance to humans
In humans, the opportunities for detecting a sex chromosome effect on neural development are limited to studies of people with spontaneous deletions, translocations or duplications of sex chromosome genes. In many cases (e.g. XO, XXY or XYY) the unusual genetic constitution also influences gonadal secretions, making it difficult to disentangle sex chromosome and hormonal effects. However, XXY and XYY boys both have testes, but have recognizable social behavior phenotypes that are different from
Conclusions and future directions
If the sex chromosome constitution of brain cells contributes to sexual differentiation, how large might this effect be? Is the recent appreciation of this effect, decades after the divergence of the fields of sex determination and brain sexual differentiation in 1959, an indication that the role of the sex chromosomes is minor relative to the main masculinizing influence of testosterone? At present, the answers to these questions are not known. It is no accident that the first cases of sex
Acknowledgements
We thank Robin Lovell-Badge for comments on this manuscript and other discussions. This work was supported by NIH grants MH59268 and NS43196 to A.P.A.
References (58)
A sex chromosome anomaly in a case of gonadal dysgenesis (Turner's syndrome)
Lancet
(1959)X-chromosome inactivation
Curr. Biol.
(1999)Sex and development in bovine in vitro fertilized embryos
Theriogenology
(1991)- et al.
Sexual differentiation of monoaminergic neurons – genetic or epigenetic
Trends Neurosci.
(1991) Sex differences of hypothalamic prolactin cells develop independently of the presence of sex steroids
Brain Res.
(1992)Sex differences in mouse cortical thickness are independent of the complement of sex chromosomes
Neuroscience
(2003)The Y chromosome, social signals, and offense in mice
Behav. Neural Biol.
(1989)Correlated effects of the Y-chromosome of mice on developmental changes in testosterone levels and intermale aggression
Life Sci.
(1977)Concepts of genetic and hormonal induction of vertebrate sexual differentiation in the twentieth century, with special reference to the brain
Neurosteroids and brain sexual differentiation
Trends Neurosci.
(2001)
A case of human intersexuality having a possible XXY sex-determining mechanism
Nature
The Y chromosome as the bearer of male determining factors in the mouse
Proc. Natl. Acad. Sci. U. S. A.
SRY and sex determination in mammals
Annu. Rev. Genet.
Reserches sur la différenciation sexuelle de l'embryon de lapin
Arch. Anat. Microsc. Morphol. Exp.
Organizing action of prenatally administered testosterone propionate on the tissues mediating mating behavior in the female guinea pig
Endocrinology
Sexual Differentiation of the Brain
Gonadal steroid induction of structural sex differences in the CNS
Annu. Rev. Neurosci.
Androgens prevent normally occurring cell death in a sexually dimorphic spinal nucleus
Science
The male-specific region of the human Y chromosome is a mosaic of discrete sequence classes
Nature
Sex differences in sex chromosome gene expression in mouse brain
Hum. Mol. Genet.
A first-generation X-inactivation profile of the human X chromosome
Proc. Natl. Acad. Sci. U. S. A.
A high density of X-linked genes for general cognitive ability: a run-away process shaping human evolution?
Trends Genet.
Weight differences in rat embryos prior to sexual differentiation
J. Embryol. Exp. Morphol.
Altered sex ratio of live young after transfer of fast- and slow-developing mouse embryos
Gamete Res.
Sex difference in mouse embryonic development at neurulation
J. Reprod. Fertil.
Assessment of embryo viability prior to transfer by the noninvasive measurement of glucose uptake
J. Exp. Zool.
Sex-related differences in developmental rates of bovine embryos produced and cultured in vitro
Mol. Reprod. Dev.
A Y-chromosomal effect on blastocyst cell number in mice
Development
The genetic basis of XX–XY differences present before gonadal sex differentiation in the mouse
Philos. Trans. R. Soc. Lond. B Biol. Sci.
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