Short synthesis of a novel class of salvinorin A analogs with hemiacetalic structure
Graphical abstract
Novel semisynthetic analogs of salvinorin A with dual affinity for κ- and μ-opioid receptors are obtained by hydrolysis with 5% aq KOH, subsequent hemiacetalization, and epimerization at C-12.
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Acknowledgments
The authors would like to acknowledge Lukasz Kutrzeba for help in extraction of salvinorin A from plant material, and Dr. Paulo Carvalho for providing crystallographic data. This work was supported by NIH Grant R01 DA017204, and conducted in a facility constructed with support from research facilities improvement program Grant C06 RR-14503-01 from National Center for Research Resources, National Institutes of Health, Bethesda, MD, USA.
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