Trends in Pharmacological Sciences
LettersThe recently deorphanized GPR80 (GPR99) proposed to be the P2Y15 receptor is not a genuine P2Y receptor
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Characterization of the UDP-glucose receptor (re-named here the P2Y14 receptor) adds diversity to the P2Y receptor family
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Cited by (52)
AMP and adenosine are both ligands for adenosine 2B receptor signaling
2018, Bioorganic and Medicinal Chemistry LettersATP as a cotransmitter in the autonomic nervous system
2015, Autonomic Neuroscience: Basic and ClinicalCitation Excerpt :The role of the endogenous nucleotide, adenosine 5′-triphosphate (ATP), as a major intracellular energy source is a well-established phenomenon. In addition, many studies have shown that ATP and related nucleotides have widespread extracellular actions via the ionotropic P2X receptors, which are ligand-gated cation channels, and metabotropic P2Y receptors, which are G protein-coupled receptors (Abbracchio et al., 2005, 2006; Burnstock and Kennedy, 1985, 2011; Kennedy et al., 2013; Khakh et al., 2001). These receptors are distributed widely throughout the body and involved in many physiological and pathophysiological processes (Burnstock and Kennedy, 2011).
Extracellular nucleotide and nucleoside signaling in vascular and blood disease
2014, BloodCitation Excerpt :In contrast to other ecto-nucleoside-triphosphate-diphosphohydrolases, CD39 is oriented as such that the catalytic side of the enzyme is facing the extracellular compartment and by its capacity to convert ATP or ADP completely to AMP.21-23 At present, there is no specific AMP receptor described24,25; however, some evidence indicates that AMP can directly activate adenosine receptors (eg, the Adora1).26 Importantly, there is compelling evidence that AMP serves as a metabolic nucleotide intermediate, which is rapidly converted to adenosine by the ecto-5′-nucleotidase CD73.
AMP is an adenosine A <inf>1</inf> receptor agonist
2012, Journal of Biological ChemistryCitation Excerpt :Although mammals have numerous P2 purinergic receptors for ATP and ADP, no receptor for their hydrolysis product (AMP) has been definitively identified. GPR80/GPR99 was originally classified as an adenosine and AMP receptor (3); however, this finding has now been discounted (4, 5). AMP has diverse physiological effects, suggesting that a receptor for AMP could exist (6–15).
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These authors contributed equally to this article.
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Chairman of the International Union of Pharmacology (IUPHAR) Subcommittee for P2Y receptor nomenclature and classification.