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The recently deorphanized GPR80 (GPR99) proposed to be the P2Y15 receptor is not a genuine P2Y receptor

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Cited by (52)

  • AMP and adenosine are both ligands for adenosine 2B receptor signaling

    2018, Bioorganic and Medicinal Chemistry Letters
  • ATP as a cotransmitter in the autonomic nervous system

    2015, Autonomic Neuroscience: Basic and Clinical
    Citation Excerpt :

    The role of the endogenous nucleotide, adenosine 5′-triphosphate (ATP), as a major intracellular energy source is a well-established phenomenon. In addition, many studies have shown that ATP and related nucleotides have widespread extracellular actions via the ionotropic P2X receptors, which are ligand-gated cation channels, and metabotropic P2Y receptors, which are G protein-coupled receptors (Abbracchio et al., 2005, 2006; Burnstock and Kennedy, 1985, 2011; Kennedy et al., 2013; Khakh et al., 2001). These receptors are distributed widely throughout the body and involved in many physiological and pathophysiological processes (Burnstock and Kennedy, 2011).

  • Extracellular nucleotide and nucleoside signaling in vascular and blood disease

    2014, Blood
    Citation Excerpt :

    In contrast to other ecto-nucleoside-triphosphate-diphosphohydrolases, CD39 is oriented as such that the catalytic side of the enzyme is facing the extracellular compartment and by its capacity to convert ATP or ADP completely to AMP.21-23 At present, there is no specific AMP receptor described24,25; however, some evidence indicates that AMP can directly activate adenosine receptors (eg, the Adora1).26 Importantly, there is compelling evidence that AMP serves as a metabolic nucleotide intermediate, which is rapidly converted to adenosine by the ecto-5′-nucleotidase CD73.

  • AMP is an adenosine A <inf>1</inf> receptor agonist

    2012, Journal of Biological Chemistry
    Citation Excerpt :

    Although mammals have numerous P2 purinergic receptors for ATP and ADP, no receptor for their hydrolysis product (AMP) has been definitively identified. GPR80/GPR99 was originally classified as an adenosine and AMP receptor (3); however, this finding has now been discounted (4, 5). AMP has diverse physiological effects, suggesting that a receptor for AMP could exist (6–15).

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These authors contributed equally to this article.

*

Chairman of the International Union of Pharmacology (IUPHAR) Subcommittee for P2Y receptor nomenclature and classification.

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